Research progress of myeloid differentiation factor 88 polymorphism

doi:10.3969/j.issn.1673-8640.2020.04.020

Abstract

Abstract:

Myeloid differentiation factor 88（MYD88）is an important adaptor protein mediating the signal transduction of Toll-like receptors（TLR）,interleukin 1 receptor（IL-1R）and interleukin 18 receptor（IL-18R）,which plays a key role in innate immunity. MYD88-dependent pathways play roles in the pathogenesis of multiple pathogens and have relations with tumors,infectious diseases,autoimmune diseases and so on,which are considered to be important targets for the intervention of these diseases. The L265P mutant in MYD88,an amino acid change（L265P）in the MYD88 Toll-like receptor/interleukin 1 receptor（TIR）,promotes Janus kinase-signal transducer and activator of transcription 3（JAK-STAT3） signaling pathway by enhancing transcription factors such as nuclear factor kappa B（NF-κB）,and mediates the production of inflammatory factors such as interleukin（IL）-6,IL-10 and interferon-beta（IFN-β）. The structure and fundamental function of MYD88 and its role in signal transduction are reviewed. Furthermore,the association between MYD88 L265P and diseases are also illustrated.

Key words: Myeloid differentiation factor 88, Toll-like receptor, Lymphoplasmacytoid lymphoma

CLC Number:

R446.1

HU Yuyi, CHEN Pu, GUO Wei, PAN Baishen. Research progress of myeloid differentiation factor 88 polymorphism[J]. Laboratory Medicine, 2020, 35(4): 380-386.

Figures/Tables 2

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