Laboratory Medicine ›› 2018, Vol. 33 ›› Issue (8): 768-769.DOI: 10.3969/j.issn.1673-8640.2018.08.022
• Orginal Article • Previous Articles Next Articles
Received:
2018-02-28
Online:
2018-08-30
Published:
2018-09-07
CLC Number:
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2018.08.022
组别 | 例数 | CEA(ng/mL) | HE4(pmol/L) |
---|---|---|---|
恶性胸腔 积液组 | 126 | 44.43 (5.23~387.30)* | 2 250.50 (795.22~3 555.00)* |
良性胸腔 积液组 | 120 | 1.08 (0.55~2.41) | 252.75 (132.27~569.50) |
组别 | 例数 | CEA(ng/mL) | HE4(pmol/L) |
---|---|---|---|
恶性胸腔 积液组 | 126 | 44.43 (5.23~387.30)* | 2 250.50 (795.22~3 555.00)* |
良性胸腔 积液组 | 120 | 1.08 (0.55~2.41) | 252.75 (132.27~569.50) |
项目 | AUC (95%可信区间) | 标准误 | P值 | 约登 指数 |
---|---|---|---|---|
CEA | 0.836(0.783~0.888) | 0.027 | 0.000 | 0.604 |
HE4 | 0.864(0.818~0.910) | 0.023 | 0.000 | 0.621 |
CEA+HE4 | 0.908(0.871~0.946) | 0.019 | 0.000 | 0.715 |
项目 | AUC (95%可信区间) | 标准误 | P值 | 约登 指数 |
---|---|---|---|---|
CEA | 0.836(0.783~0.888) | 0.027 | 0.000 | 0.604 |
HE4 | 0.864(0.818~0.910) | 0.023 | 0.000 | 0.621 |
CEA+HE4 | 0.908(0.871~0.946) | 0.019 | 0.000 | 0.715 |
[1] | BARBIERI R L.In women who have a pelvic mass. Have you tried this new ovarian Ca biomarker?[J]. OBG Management,2010,22(4):8-12. |
[2] | 应海平. 胸水ADA和CEA检测在胸腔积液中的鉴别诊断价值[J]. 现代实用医学,2006,18(6):390. |
[3] | 刘娟,刘纯,彭林. 多种肿瘤标志物联合检测在良恶性胸水中的诊断价值[J]. 医学临床研究,2007,24(3):469-471. |
[4] | MOORE R G,HILL E K,HORAN T,et al.HE4(WFDC2) gene overexpression promotes ovarian tumor growth[J]. Sci Rep,2014,4:3574. |
[5] | 肖然,胡昊昀,王瑞,等. 血清肿瘤标志物HE4检测在肺癌诊断中的应用价值探讨[J]. 检验医学,2014,29(9):893-896. |
[6] | ZENG Q,LIU M,ZHOU N,et al.Serum human epididymis protein 4(HE4) may be a better tumor marker in early lung cancer[J]. Clin Chim Acta,2016,455:102-106. |
[7] | KAMEI M,YAMASHITA S,TOKUISHI K,et al.HE4 expression can be associated with lymph node metastases and disease-free survival in breast cancer[J]. Anticancer Res,2010,30(11):4779-4783. |
[8] | XI Z,LINLIN M,YE T.Human epididymis protein 4 is a biomarker for transitional cell carcinoma in the urinary system[J]. J Clin Lab Anal,2009,23(6):357-361. |
[9] | IWAHORI K,SUZUKI H,KISHI Y,et al.Serum HE4 as a diagnostic and prognostic marker for lung cancer[J]. Tumour Biol,2012,33(4):1141-1149. |
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