Abstract:

Objective To investigate the roles of reticulated platelet （RP） and related parameters in children with immunological thrombocytopenia （ITP） and sepsis. Methods A total of 30 newly diagnosed children with ITP,30 children with sepsis, 20 children with aplastic anemia （AA）（disease control group） and 30 healthy children （healthy control group） were enrolled. Their blood specimens were collected. Reticulated platelet ratio （RP%）,RP absolute value,mean platelet volume （MPV）,platelet distribution width （PDW） were determined. Results RP%, MPV and PDW in ITP and sepsis groups were higher than those in disease control and healthy control groups （P<0.05）, and those in ITP group were higher than those in sepsis group （P<0.05）. The RP absolute values in ITP and sepsis groups were lower than that in healthy control group （P<0.05）. There was no statistical significance for RP%, MPV and PDW between disease control and healthy control groups （P>0.05）. Conclusions The determinations of RP and platelet（PLT）related parameters can be used for the differential diagnosis of child diseases caused by ITP and sepsis. The determinations of RP and related parameters play roles in the assessment of bone marrow hematopoietic function.

Key words: Reticulated platelet, Reticulated platelet parameters, Child immunological thrombocytopenia, Child sepsis