Abstract:

Objective To provide the reference of pathogenic diagnosis and clinical medication for 1 case with chronic osteomyelitis of femur. Methods Anaerobic,aerobic and microaerobic cultures and the identification of bacteria from fester and tissue specimens obtained during operation were performed by smear and microscopy. The in vitro drug susceptibility test was performed by disk diffusion and E-test methods. Results Facultative anaerobic Streptococcus anginosus,obligate anaerobic Veillonella parvula and microaerophilic bacillus Aeromonas foam were isolated from wound tissues. The in vitro drug susceptibility test showed that they were highly sensitive to piperacillin-tazobactam,meropenem and vancomycin. Clinical medication program was as follows：preoperative and postoperative intravenous drip of piperacillin-tazobactam,medullary cavity with bone cement implantation of imipenem and vancomycin,artificial bone implantation with meropenem and vancomycin, and repair of muscle flap. The patient recovered after the above treatments. Conclusions Special attention should be paid to the patient with chronic osteomyelitis. All pathogens should be isolated,and drug susceptibility test should be performed. Individual medication program should be laid down and performed,which is a prerequisite for a thorough treatment of infection.

Key words: Streptococcus anginosus, Veillonella parvula, Aeromonas foam, Mixed infection, Chronic osteomyelitis