Abstract:

Objective To investigate the correlation between septicopyemia patients' blood glucose levels and their prognosis. Methods A total of 118 septicopyemia patients were enrolled,and their results were analyzed retrospectively. According to the blood glucose levels after controlling by insulin,the patients were classified into 3 groups, normal blood glucose group（4.0-6.1 mmol/L）,mildly high blood glucose group（6.2-8.3 mmol/L） and high blood glucose group（8.4-10.0 mmol/L）. The differences of glycated hemoglobin A_1c（HbA_1c）,multiple organ dysfunction syndrome（MODS） incidence rate,intensive care unit（ICU） staying day,antibiotic usage time,ventilation usage time,the number of deaths and acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ）score among the 3 groups were analyzed. Results The incidence rate of MODS（40.4%）,ICU staying day [（14.15 ± 1.40）d],antibiotic usage time [（11.79 ± 1.76）d],ventilation usage time [（8.36 ± 1.07）d],the mortality rate（44.7%）and APACHE Ⅱ score（22.26 ± 1.75）in high blood glucose group were much higher than those in mildly high blood glucose group [18.2%,（7.67±2.01）d,（7.97±1.45）d,（5.73±1.10）d,21.2% and 14.94±1.48] and normal blood glucose group [13.9%,（7.29±1.74）d,（6.05±2.01）d,（5.11±0.98）d,15.8% and 13.63±1.17]（P<0.01）. The antibiotic usage time,ventilation usage time and APACHE Ⅱ score in mildly high blood glucose group were significantly higher than those in normal blood glucose group（P<0.05）. However,there was no statistical significance for ICU staying day,MODS incidence rate and mortality rate between the 2 groups（P >0.05）. There was no statistical significance for HbA_1c among the 3 groups（P >0.01）. Conclusions Septicopyemia patients with increasing blood glucose levels after controlling by insulin may suffer with a serious illness and poor prognosis. With increasing blood glucose levels,the mortality rate of patients may elevate. The control of blood glucose levels can improve prognosis among septicopyemia patients.

Key words: Septicopyemia, Blood glucose, Prognosis, Multiple organ dysfunction syndrome