Abstract: To investigate the relationships of the levels of serum iron（Fe）， ferritin（Ferr）， transferrin（TRF）， haptoglobin（Hp） and alpha2-macroglobulin（α2-MG） with common liver diseases. Methods　The Fe levels of 98 hepatitis B patients（chronic hepatitis group）， 80 patients with liver cirrhosis （liver cirrhosis group） and 60 healthy subjects （control group） were determined by Hitachi 7170A automatic biochemical analyzer. The serum Fe， TRF， Hp and α2-MG levels in the 3 groups were detected by Siemens automatic specific protein instrument （BNP）. Results　In chronic hepatitis group， the Fe level （30.40±4.80）μmol/L and Ferr level （256.00±48.00）μg/L were higher than those in the control group （P<0.05）. The TRF level （2.18±0.20）g/L and Hp level （0.66±0.32）g/L were significantly lower than those in the control group（P<0.05）. The α2-MG level （2.28±0.39） g/L was slightly higher than that in the control group， but without statistical significance （P>0.05）. In liver cirrhosis group， the Fe level （33.60±5.00）μmol/L and Ferr level （287.00±51.00）μg/L were higher than those in the control group （P<0.05）. The TRF level （2.00±0.18）g/L and Hp level （0.52±0.30）g/L were lower than those in the control group （P<0.05）.The α2-MG level （2.30±0.40）g/L was slightly higher than that in the control group， but with no statistical significance （P>0.05）. Conclusions　Serum Fe，Ferr，TRF，Hp and α2-MG levels can be important indices for predicting the degree of liver diseases， and have significance for disease diagnosis and treatment.

Key words: Serum iron, Ferritin, Transferrin, Haptoglobin, A-macroglobulin, Chronic hepatitis, Liver cirrhosis