Abstract:

Objective To analyze the epidemiological and etiological characteristics of hand-foot-mouth disease （HFMD） in Chengde from 2014 to 2023，and to provide scientific basis for formulating prevention and control measures. Methods By collecting the case information of HFMD in Chengde from 2014 to 2023 in China Disease Prevention and Control Information System and the data from the Chengde Immunization Planning Information Management System，descriptive epidemiological methods were used to analyze the three-dimensional distribution，etiological change trend and vaccination status. Results A total of 22 142 HFMD cases were reported in Chengde from 2014 to 2023，with an average annual incidence rate of 63.32/100 000，showing a fluctuating downward trend （χ²=6 464.31，P<0.01）. Totally，16 severe cases were reported，and no death occurred. The peak period of HFMD mainly occurred from June to August，with a small increase from October to November，forming a secondary peak. The incidence rate of males（74.05/100 000）was higher than that of females（52.11/100 000）（χ²= 664.42，P<0.01）. The age of onset was mainly concentrated in children under 5 years old，with the highest incidence rate in children aged 1-2 years. The majority was scattered children（66.63%）. The top 3 regions in terms of incidence were Shuangqiao District（99.87/100 000），Shuangluan District（98.95/100 000）and Kuancheng County（84.49/100 000）. The proportion of enterovirus 71 decreased sharply，while other enteroviruses became the dominant strains. The vaccination rate of enterovirus 71 vaccine showed an upward trend year by year（χ²=31 632.25，P<0.01），but the overall vaccination rate was only 3.71%. Conclusions The incidence of HFMD in Chengde has obvious differences in population，season and region. Enterovirus 71 and coxsackievirus A16 are no longer the main pathogens. Attention should be paid to the changing trend of pathogen types，strengthen the typing determination of other enteroviruses，and strengthen the promotion of vaccines and the popularization of prevention and control knowledge in high-incidence areas and key populations.

Key words: Hand-foot-mouth disease, Epidemiological characteristic, Incidence rate, Etiology, Chengde