Abstract:

Objective To understand the pathogen spectrum and epidemiological characteristics of infectious diarrhea in Wuxi. Methods The stool specimens from outpatients with diarrhea were collected from sentinel hospitals from January to December 2014. The nucleic acid of norovirus,rotavirus,enteric adenovirus,human astrovirus and sapovirus was determined by real-time fluorescence polymerase chain reaction（PCR）. Diarrheagenic Escherichia coli,Salmonella spp,Shigella spp,Vibrio parahaemolyticus and Vibrio cholerae were identified by conventional culture methods. Pathogenic composition,seasonal variation and population distribution were analyzed. Results A total of 915 specimens were monitored. The positive rate of viral nucleic acid was 14.4%,and norovirus（9.4%） and rotavirus（3.4%） showed obvious seasonal distribution characteristics with the peak incidence occurring in winter and spring. The infection rate of children of 0-5 years old was higher than those of the other age groups. Bacteria,with the positive rate 15.0%,were isolated from June to September. Salmonella spp（6.0%） was the main isolate whose predominant serotypes were Salmonella enteritidis and Salmonella typhimurium,and the second was diarrheagenic Escherichia coli（4.6%）. Conclusions The viral diarrhea deserves attention in winter and spring,norovirus and rotavirus are the common pathogens. The bacterial diarrhea is given priority in summer,whose dominant pathogens are Salmonella spp and diarrheagenic Escherichia coli. Children under 5 years old are main for the prevention and control of viral diarrhea.

Key words: Infectious diarrhea, Pathogen spectrum, Epidemiological characteristic