Laboratory Medicine ›› 2025, Vol. 40 ›› Issue (12): 1237-1240.DOI: 10.3969/j.issn.1673-8640.2025.12.017
Received:2024-04-25
Revised:2025-07-24
Online:2025-12-30
Published:2025-12-26
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2025.12.017
| 抗菌药物 | 病例1分离株 | 病例2分离株 |
|---|---|---|
| 青霉素 | =0.12（敏感） | =0.12（敏感） |
| 头孢曲松 | ≤0.12（敏感） | =0.25（敏感） |
| 美罗培南 | ≤0.25（敏感） | ≤0.25（敏感） |
| 左氧氟沙星 | ≤2（敏感） | ≤2（敏感） |
| 红霉素 | ≤0.12（敏感） | ≥1（耐药） |
| 万古霉素 | ≤0.5（敏感） | ≤0.5（敏感） |
| 利奈唑胺 | ≤2（敏感） | ≤2（敏感） |
| 氨苄西林 | ≤0.25（敏感） | ≤0.25（敏感） |
| 头孢吡肟 | ≤0.25（敏感） | ≤0.25（敏感） |
| 阿莫西林 | ≤0.06（敏感） | ≤0.06（敏感） |
| 头孢他啶 | ≤0.12（敏感） | =0.25（敏感） |
| 厄他培南 | ≤0.5（敏感） | ≤0.5（敏感） |
| 氧氟沙星 | ≤1（敏感） | ≤1（敏感） |
| 四环素 | ≤1（敏感） | ≥16（耐药） |
| 氯霉素 | ≤2（敏感） | ≤2（敏感） |
| 复方磺胺甲噁唑 | ≤10（敏感） | ≤10（敏感） |
| 抗菌药物 | 病例1分离株 | 病例2分离株 |
|---|---|---|
| 青霉素 | =0.12（敏感） | =0.12（敏感） |
| 头孢曲松 | ≤0.12（敏感） | =0.25（敏感） |
| 美罗培南 | ≤0.25（敏感） | ≤0.25（敏感） |
| 左氧氟沙星 | ≤2（敏感） | ≤2（敏感） |
| 红霉素 | ≤0.12（敏感） | ≥1（耐药） |
| 万古霉素 | ≤0.5（敏感） | ≤0.5（敏感） |
| 利奈唑胺 | ≤2（敏感） | ≤2（敏感） |
| 氨苄西林 | ≤0.25（敏感） | ≤0.25（敏感） |
| 头孢吡肟 | ≤0.25（敏感） | ≤0.25（敏感） |
| 阿莫西林 | ≤0.06（敏感） | ≤0.06（敏感） |
| 头孢他啶 | ≤0.12（敏感） | =0.25（敏感） |
| 厄他培南 | ≤0.5（敏感） | ≤0.5（敏感） |
| 氧氟沙星 | ≤1（敏感） | ≤1（敏感） |
| 四环素 | ≤1（敏感） | ≥16（耐药） |
| 氯霉素 | ≤2（敏感） | ≤2（敏感） |
| 复方磺胺甲噁唑 | ≤10（敏感） | ≤10（敏感） |
| 毒力因子 | 相关基因 | 基因位点数 | |||
|---|---|---|---|---|---|
| 病例1 | 病例2 | 05ZYH33 | 98HAH33 | ||
| 黏附相关 | |||||
| 凝集素受体 | 未确定 | 1 | 1 | 1 | 1 |
| 胆碱结合蛋白 | cbpD | 1 | 1 | 1 | 1 |
| 纤连蛋白结合蛋白 | fbp54 | 0 | 0 | 1 | 1 |
| pavA | 1 | 1 | 0 | 0 | |
| 溶菌酶释放蛋白 | mrp | 1 | 0 | 1 | 1 |
| 链球菌纤溶酶受体/甘油醛-3-磷酸脱氢酶 | plr/gapA | 1 | 1 | 0 | 0 |
| 酶类 | |||||
| 链球菌烯醇化酶 | eno | 1 | 1 | 0 | 0 |
| 免疫逃逸 | |||||
| 荚膜多糖 | 未确定 | 18 | 18 | 18 | 19 |
| 蛋白酶类 | |||||
| 胞外因子 | epf | 1 | 1 | 1 | 1 |
| 触发因子 | tig/ropA | 1 | 1 | 0 | 0 |
| 锌金属蛋白酶 | zmpC | 1 | 0 | 1 | 1 |
| 毒素类 | |||||
| 溶血素 | sly | 1 | 1 | 1 | 1 |
| 毒力因子 | 相关基因 | 基因位点数 | |||
|---|---|---|---|---|---|
| 病例1 | 病例2 | 05ZYH33 | 98HAH33 | ||
| 黏附相关 | |||||
| 凝集素受体 | 未确定 | 1 | 1 | 1 | 1 |
| 胆碱结合蛋白 | cbpD | 1 | 1 | 1 | 1 |
| 纤连蛋白结合蛋白 | fbp54 | 0 | 0 | 1 | 1 |
| pavA | 1 | 1 | 0 | 0 | |
| 溶菌酶释放蛋白 | mrp | 1 | 0 | 1 | 1 |
| 链球菌纤溶酶受体/甘油醛-3-磷酸脱氢酶 | plr/gapA | 1 | 1 | 0 | 0 |
| 酶类 | |||||
| 链球菌烯醇化酶 | eno | 1 | 1 | 0 | 0 |
| 免疫逃逸 | |||||
| 荚膜多糖 | 未确定 | 18 | 18 | 18 | 19 |
| 蛋白酶类 | |||||
| 胞外因子 | epf | 1 | 1 | 1 | 1 |
| 触发因子 | tig/ropA | 1 | 1 | 0 | 0 |
| 锌金属蛋白酶 | zmpC | 1 | 0 | 1 | 1 |
| 毒素类 | |||||
| 溶血素 | sly | 1 | 1 | 1 | 1 |
| [1] |
NHUNG N T, YEN N T P, CUONG N, et al. Carriage of the zoonotic organism Streptococcus suis in chicken flocks in Vietnam[J]. Zoonoses Public Health, 2020, 67(8):843-848.
DOI URL |
| [2] |
NEILA-IBÁÑEZ C, NAPP S, PAILLER-GARCÍA L, et al. Risk factors associated with Streptococcus suis cases on pig farms in Spain[J]. Vet Rec, 2023, 193(5):e3056.
DOI URL |
| [3] |
ZHU Y, ZHU F, BO L, et al. A rare case of meningitis and septicemia caused by Streptococcus suis in a woman without a history of live pig contact or eating raw pork[J]. Braz J Microbiol, 2021, 52(4):2007-2012.
DOI |
| [4] |
PEI X, LIU M, ZHOU H, et al. Screening for phagocytosis resistance-related genes via a transposon mutant library of Streptococcus suis serotype 2[J]. Virulence, 2020, 11(1):825-838.
DOI URL |
| [5] |
LI Z, XU M, HUA X. Endogenous endophthalmitis caused by Streptococcus suis infection:a case report[J]. BMC Ophthalmol, 2022, 22(1):165.
DOI |
| [6] |
XU L, WANG X, LEI Z, et al. Spinal canal infection caused by Streptococcus suis in human:a case report[J]. BMC Infect Dis, 2022, 22(1):369.
DOI |
| [7] |
MIKI T, OHKI S, OBAYASHI T, et al. Aortic and tricuspid valve infective endocarditis caused by Streptococcus suis[J]. Asian Cardiovasc Thorac Ann, 2019, 27(9):751-753.
DOI URL |
| [8] |
CAHYANINGTYAS C, RAHMAWATI, MUSLICH L T, et al. A Streptococcus suis infection causing pneumonia in Indonesia:a case report[J]. Radiol Case Rep, 2022, 17(11):4337-4340.
DOI URL |
| [9] |
YU H, JING H, CHEN Z, et al. Human Streptococcus suis outbreak,Sichuan,China[J]. Emerg Infect Dis, 2006, 12(6):914-920.
DOI URL |
| [10] |
RAYANAKORN A, KATIP W, GOH B H, et al. Clinical manifestations and risk factors of Streptococcus suis mortality among northern Thai population:retrospective 13-year cohort study[J]. Infect Drug Resist, 2019,12:3955-3965.
DOI URL |
| [11] | VAN SAMKAR A, BROUWER M C, SCHULTSZ C, et al. Streptococcus suis meningitis:a systematic review and meta-analysis[J]. PLoS Negl Trop Dis, 2015, 9(10):4191. |
| [12] |
RAYANAKORN A, GOH B H, LEE L H, et al. Risk factors for Streptococcus suis infection:a systematic review and meta-analysis[J]. Sci Rep, 2018, 8(1):13358.
DOI |
| [13] |
PANG X, MA L, ZHUO L, et al. The first report of human primary pyogenic ventriculitis caused by Streptococcus suis:a case report[J]. Ann Palliat Med, 2021, 10(7):8448-8453.
DOI URL |
| [14] | 萧松建, 周奕. 2018—2023年广东省珠海市人感染猪链球菌病流行病学和临床特征分析[J]. 现代疾病预防控制, 2024, 35(12):927-930. |
| [15] |
孙健, 王妮, 侯为顺. 人感染猪链球菌病1例[J]. 中国感染与化疗杂志, 2024, 24(6):720-722.
DOI |
| [16] | 方锦涛. 抗菌药物联合用药对猪链球菌体外和体内药效学评价[D]. 广州: 华南农业大学, 2017. |
| [17] | BRIZUELA J, KAJEEKUL R, ROODSANT T J, et al. Streptococcus suis outbreak caused by an emerging zoonotic strain with acquired multi-drug resistance in Thailand[J]. Microb Genom, 2023, 9(2):mgen000952. |
| [18] |
LI L, ZHANG Q, ZHAO X, et al. Rapid detection of mrp,epf,and sly genes by loop-mediated isothermal amplification in Streptococcus suis[J]. Foodborne Pathog Dis, 2021, 18(4):290-296.
DOI URL |
| [19] | YANG H, HUANG J, HU X, et al. Comparative genome analysis of Streptococcus suis serotype 9 isolates from China,the Netherland,and the U.K[J]. Life(Basel), 2021, 11(12):1324. |
| [20] | 张泽辉. 辽宁地区奶牛乳房炎源大肠杆菌毒力与耐药相关性研究[D]. 沈阳: 沈阳农业大学, 2017. |
| [21] | JI L, CHEN Z, LI F, et al. Epidemiological and genomic analyses of human isolates of Streptococcus suis between 2005 and 2021 in Shenzhen,China[J]. Front Microbiol, 2023, 14:1118056. |
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