Abstract:

Objective To investigate the clinical roles of serum dehydroepiandrosterone sulfate（DHEA-S），sex hormone-binding globulin（SHBG） and 17 alpha-hydroxyprogesterone（17α-OHP） levels in patients with polycystic ovary syndrome（PCOS）. Methods A total of 110 PCOS patients（PCOS group） and 550 healthy females（healthy control group） were enrolled from Fengcheng Hospital of Fengxian District from January 1，2020 to March 8，2023. Serum levels of DHEA-S，SHBG and 17α-OHP were determined. Multivariate Logistic regression analysis was used to evaluate the risk factors of PCOS. Receiver operating characteristic（ROC） curve was used to evaluate the efficacy of DHEA-S，SHBG and 17α-OHP in the diagnosis of PCOS. Results The serum DHEA-S and 17α-OHP levels in PCOS group were higher than those in healthy control group（P<0.01），and serum SHBG levels were lower than those in healthy control group（P<0.01）. DHEA-S，SHBG and 17α-OHP were all risk factors for PCOS [odds ratios（OR） were 3.546，0.931 and 5.742，95% confidence intervals（CI） were 1.504~8.448，0.882~0.982，1.869~17.648，respectively，P<0.01]. The areas under curves（AUC） of DHEA-S，SHBG and 17α-OHP for the diagnosis of PCOS were 0.823，0.868，0.869 and 0.968，respectively. Conclusions Serum DHEA-S and 17α-OHP levels in PCOS patients are increased，while SHBG levels are decreased. The combined determination of DHEA-S，SHBG and 17α-OHP levels in PCOS patients has high clinical value in the auxiliary diagnosis of PCOS.

Key words: Dehydroepiandrosterone sulfate, Sex hormone-binding globulin, 17 Alpha-hydroxyprogesterone, Polycystic ovary syndrome