Abstract:

Objective To investigate the correlation between thrombelastogram（TEG） and disseminated intravascular coagulation（DIC） and its diagnostic value. Methods From March 2017 to November 2018,96 patients with suspected DIC in intensive care unit of Beijing Tiantan Hospital of Capital Medical University were enrolled. Totally,36 patients with DIC were enrolled as study group,and 60 patients without DIC were enrolled as control group. Conventional coagulation indexes and TEG indexes were determined,and TEG indexes of dead patients and non-dead patients were compared. The sensitivities and specificities of conventional coagulation indexes and TEG indexes in the diagnosis of DIC were evaluated by receiver operating characteristic（ROC） curve. The influence of TEG on the diagnosis of DIC was analyzed with single factor Logistic analysis. Results The reaction（R） time and clot formation（K） time of TEG in study group were longer than those in control group（P<0.05）,and the angle alpha（α）,maximum amplitude（MA） and coagulation index（CI） in study group were smaller than those in control group（P<0.05）. In the study group,the R time and K time of dead DIC patients were prolonged（P<0.05）,the α angle,MA and CI were reduced compared with non-dead DIC patients. In the study group,there was statistical significance in the conventional coagulation indexes between dead and non-dead DIC patients（P<0.05）. The sensitivities and specificities of conventional coagulation indexes were lower than those of TEG indexes. In single factor Logistic analysis,R time,K time,α angle,MA,CI,international normalized ratio（INR） and fibrinogen（Fib） were risk factors（P<0.05）. Conclusions TEG indexes and conventional coagulation indexes can be used in predicting the risk of DIC,and TEG indexes have higher diagnostic specificities,which have guiding significance for the early diagnosis and prognosis prevention of DIC.

Key words: Thrombelastogram, Disseminated intravascular coagulation, Coagulation index