Abstract:

Objective To assess the roles of procalcitonin （PCT）,D-dimer （DD） and mean platelet volume （MPV） for the early diagnosis and curative effect monitoring of severe acute pancreatitis （SAP）. Methods A total of 75 patients with acute pancreatitis（AP） were enrolled,including 45 cases of mild acute pancreatitis（MAP） and 30 cases of SAP. The levels of PCT,DD and MPV were determined before treatment and after treatment for 24 h,48 h and 7 d. Receiver operating characteristic （ROC） curve was used for evaluating diagnostic effects. The sensitivities,specificities,positive predictive values and negative predictive values of PCT,DD and MPV for the diagnosis of SAP were evaluated before treatment. After treatment for 24 h,48 h and 7 d,the curative effects and the changes of PCT,DD and MPV in patients with SAP were evaluated and compared. Results The levels of PCT,DD and MPV were higher in SAP group than those in MAP group （P=0.000）. ROC curves showed that the areas under curves were 0.929,0.856 and 0.936. The sensitivity and specificity of PCT determination were 93.3% and 80.0%,the sensitivity and specificity of DD determination were 73.3% and 80.0%,the sensitivity and specificity of MPV determination were 70.0% and 86.7%,respectively. The sensitivity of the combined determination of PCT, DD and MPV was 96.7%,and the specificity was 97.8%. After treatment for 24 h, 48 h and 7 d,the levels of PCT,DD and MPV were decreased in patients with SAP （P<0.05）. Conclusions The combined determination of PCT,DD and MPV plays a role in the diagnosis and curative effect monitoring of SAP.

Key words: Procalcitonin, D-dimer, Mean platelet volume, Severe acute pancreatitis