Application and progress of next-generation sequencing technology in non-invasive prenatal testing

doi:10.3969/j.issn.1673-8640.2016.06.021

Abstract

Abstract:

This article briefly introduces cell-free fetal DNA（cff DNA） in maternal circulations,followed by polymerase chain reaction（PCR） application in prenatal diagnosis. The paper mainly includes the following aspects： sequencing approach,datum analysis and interpretation,current clinical application as well as quality control. Finally,the paper describes the future applications of next-generation sequencing technology in maternal malignacy determination during prenatal testing.

Key words: Next-generation sequencing technology, Non-invasive prenatal testing, Cell-free fetal DNA

CLC Number:

R446.1

BAO Yun, XIAO Yanqun, WANG Hualiang. Application and progress of next-generation sequencing technology in non-invasive prenatal testing[J]. Laboratory Medicine, 2016, 31(6): 541-545.

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