Application of inductively coupled plasma mass spectrometry in clinical laboratory medicine

doi:10.3969/j.issn.1673-8640.2025.11.017

Abstract

Abstract:

Inductively coupled plasma mass spectrometry （ICP-MS） has been widely applied in environmental monitoring，food，pharmaceuticals，public health and so on. In the recent years，ICP-MS has begun to be promoted and applied in the field of clinical laboratory medicine. This review focuses on the application of ICP-MS in clinical laboratory medicine，including clinical determination，standardization and reference methods，as well as other research aspects，and it provides a future outlook.

Key words: Inductively coupled plasma mass spectrometry, Clinical laboratory medicine, Application

CLC Number:

R446

FAN Xiaoyu, LI Qing, TU Jiaxin, JIN Zhonggan, YU Keying, SUN Hewei, LUO Xialin, JU Yi. Application of inductively coupled plasma mass spectrometry in clinical laboratory medicine[J]. Laboratory Medicine, 2025, 40(11): 1126-1131.

Figures/Tables 3

References 57

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方法	检测限						检测效率	抗基质干扰	样本用量	安全性
方法	钙/ （µg·L^-1）	镁/ （µg·L^-1）	铁/ （µg·L^-1）	锌/ （µg·L^-1）	铜/ （µg·L^-1）	铅/ （µg·L^-1）	检测效率	抗基质干扰	样本用量	安全性
ICP-MS	0.500	0.007	0.400	0.003	0.003	0.031	每次同时检测多元素	强	小	惰性气体
AAS	1.5	0.1	5.0	1.5	1.5	0.2	每次检测单一元素	弱	大	可燃气体

方法	检测限						检测效率	抗基质干扰	样本用量	安全性
方法	钙/ （µg·L^-1）	镁/ （µg·L^-1）	铁/ （µg·L^-1）	锌/ （µg·L^-1）	铜/ （µg·L^-1）	铅/ （µg·L^-1）	检测效率	抗基质干扰	样本用量	安全性
ICP-MS	0.500	0.007	0.400	0.003	0.003	0.031	每次同时检测多元素	强	小	惰性气体
AAS	1.5	0.1	5.0	1.5	1.5	0.2	每次检测单一元素	弱	大	可燃气体

项目	ICP-MS	LC-MS/MS
前处理	简单、快速	复杂、耗时
检测效率	多元素标记，效率高	效率较低
标准化	易于标准化	标准化困难

项目	ICP-MS	LC-MS/MS
前处理	简单、快速	复杂、耗时
检测效率	多元素标记，效率高	效率较低
标准化	易于标准化	标准化困难