Abstract:

Objective To investigate the expressions of milk fat globule-epidermal growth factor-8（MFG-E8） and G protein subunit alpha 14（GNA14） in endometriosis associated ovarian cancer（EAOC）. Methods A total of 51 patients with EAOC（EAOC group），63 patients with atypical endometriosis（AEM）（AEM group） and 82 patients with ovarian endometriosis（EMT）（EMT group） were enrolled from Fengfeng General Hospital of North China Medical and Health Group from May 2015 to May 2017. The clinical data of all the patients were collected，and the expressions of MFG-E8 and GNA14 in pathological tissues were determined. The EAOC patients were followed up for 5 years. Kaplan-Meier survival curve was used to analyze the survival of EAOC patients. Multivariate Cox regression analysis was used to evaluate the risk factors of death in EAOC patients. Results The positive rates of MFG-E8 and GNA14 in EAOC group were 82.35% and 70.59%，respectively，which were higher than those in AEM group（41.27%，44.44%） and EMT group（25.61%，23.17%）（P<0.001）. There was statistical significance in tumor diameter，tumor grade，the International Federation of Gynecology and Obstetrics（FIGO） stage and lymphatic metastasis between MFG-E8 high expression group and low expression group（P<0.05）. There was statistical significance in lymphatic metastasis between GNA14 high expression group and low expression group（P=0.009）. The progression-free survival times of MFG-E8 high expression group and GNA14 high expression group were shorter than those of MFG-E8 low expression group and GNA14 low expression group，respectively（P<0.05）. FIGO stage Ⅱ，lymphatic metastasis，MFG-E8 high expression and GNA14 high expression were independent risk factors for death in EAOC patients [hazard ratios（HR） were 2.337，2.519，3.133 and 3.080，95% confidence intervals（CI） were 1.258-4.342，1.332-4.764，1.381-7.108 and 1.318-7.197，respectively，P<0.01]. Conclusions MFG-E8 and GNA14 are highly expressed in cancer tissues of EAOC patients，and they are related to poor prognosis of patients，which may be used as prognostic indicators of EAOC patients.

Key words: Milk fat globule-epidermal growth factor-8, G protein subunit alpha 14, Endometriosis, Qvarian cancer