Abstract:

Objective To investigate the relation of angiogenic factor with G patch and FHA domain 1（AGGF1） in peripheral blood and coronary artery stenosis. Methods A total of 116 patients at TEDA International Cardiovascular Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College from June 2011 to November 2015 were enrolled. According to coronary angiography results，the 116 patients were classified into case group（coronary artery stenosis>50%，82 cases） and control group（coronary artery stenosis≤50%，34 cases）. Non-conditional multifactor stepwise Logistic regression analysis and receiver operating characteristic（ROC） curve were used to evaluate the risk factors for coronary artery stenosis>50% and the diagnostic efficacy in coronary artery stenosis of AGGF1 combined with high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C），respectively. The 34 patients from control group were followed up，and the predictive value of AGGF1 in the occurrence of major adverse cardiovascular events（MACE） was evaluated. Results The level of AGGF1 in case group was lower than that in control group（P<0.001）. Decreased AGGF1 was a risk factor for coronary artery stenosis>50% [odds ratio（OR）=0.536，95% confidence interval（CI） 0.368-0.782]. AGGF1 combined with HDL-C and LDL-C had an area under curve of 0.815 for the diagnosis of coronary artery stenosis. The follow-up of control group showed that there was no MACE in high AGGF1 patients and 6 cases in low AGGF1 patients. Conclusions Decreased AGGF1 in peripheral blood is a risk factor for coronary artery stenosis>50%. AGGF1 combined with HDL-C and LDL-C has a high diagnostic efficacy for the diagnosis of coronary artery stenosis，and decreased AGGF1 may have a certain predictive value for the long-term occurrence of MACE in coronary artery stenosis≤50%.

Key words: Angiogenic factor with G patch and FHA domain 1, Coronary artery stenosis, Coronary angiography