Laboratory Medicine ›› 2021, Vol. 36 ›› Issue (2): 153-161.DOI: 10.3969/j.issn.1673-8640.2021.02.007
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ZENG Peipei1, ZENG Ting1, DENG Liangqiong1, GUO Hao2, FENG Yushan1, HUANG Liping1, LI Honghui1()
Received:
2020-05-21
Online:
2021-02-28
Published:
2021-02-28
Contact:
LI Honghui,E-mail:lzfyebzx@126.com.
CLC Number:
ZENG Peipei, ZENG Ting, DENG Liangqiong, GUO Hao, FENG Yushan, HUANG Liping, LI Honghui. Analysis on changes of gut microbiota in children with autism spectrum disorder based on high-throughput sequencing[J]. Laboratory Medicine, 2021, 36(2): 153-161.
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2021.02.007
组别 | 罕见小球 菌属 | 霍尔德曼 菌属 | Candidatus Saccharibacteria noname属 | 普雷沃 菌属 | Burkholderiales noname属 | 戈登杆菌属 | 另枝 菌属 |
---|---|---|---|---|---|---|---|
ASD组 | 2.08 | 0.04 | 0.002 | 3.61 | 0.09 | 0.012 | 6.34 |
正常对照组 | 0.74 | 0.02 | 0.009 | 3.39 | 0.04 | 0.01 | 2.44 |
统计值 | 842.0 | 827.0 | 471.0 | 814.0 | 802.0 | 800.0 | 808.0 |
P值 | 0.007 | 0.008 | 0.017 | 0.018 | 0.018 | 0.02 | 0.022 |
组别 | Solobacterium属 | Parasutterella属 | Anaerotruncus属 | 杆菌属 | 丛毛单胞 菌属 | 孪生球菌属 | 颗粒球 菌属 |
ASD组 | 0.001 | 0.14 | 0.16 | 0 | 0.001 | 0.012 | 0.012 |
正常对照组 | 0.002 | 0.05 | 0.09 | 0.001 | 0 | 0.03 | 0.04 |
统计值 | 469.5 | 793.0 | 785.0 | 542.5 | 682.5 | 444.0 | 444.0 |
P值 | 0.022 | 0.03 | 0.042 | 0.042 | 0.042 | 0.046 | 0.048 |
组别 | 罕见小球 菌属 | 霍尔德曼 菌属 | Candidatus Saccharibacteria noname属 | 普雷沃 菌属 | Burkholderiales noname属 | 戈登杆菌属 | 另枝 菌属 |
---|---|---|---|---|---|---|---|
ASD组 | 2.08 | 0.04 | 0.002 | 3.61 | 0.09 | 0.012 | 6.34 |
正常对照组 | 0.74 | 0.02 | 0.009 | 3.39 | 0.04 | 0.01 | 2.44 |
统计值 | 842.0 | 827.0 | 471.0 | 814.0 | 802.0 | 800.0 | 808.0 |
P值 | 0.007 | 0.008 | 0.017 | 0.018 | 0.018 | 0.02 | 0.022 |
组别 | Solobacterium属 | Parasutterella属 | Anaerotruncus属 | 杆菌属 | 丛毛单胞 菌属 | 孪生球菌属 | 颗粒球 菌属 |
ASD组 | 0.001 | 0.14 | 0.16 | 0 | 0.001 | 0.012 | 0.012 |
正常对照组 | 0.002 | 0.05 | 0.09 | 0.001 | 0 | 0.03 | 0.04 |
统计值 | 469.5 | 793.0 | 785.0 | 542.5 | 682.5 | 444.0 | 444.0 |
P值 | 0.022 | 0.03 | 0.042 | 0.042 | 0.042 | 0.046 | 0.048 |
组别 | 翁德顿氏 另枝菌 | Alistipes putredinis | 毗邻颗粒链球菌 | 芬戈尔德氏拟杆菌 | 谢氏另 枝菌 | 前庭链球菌 | 死亡梭杆菌 | 丝状霍尔德曼菌 | 芽胞拟杆菌 | 伯克霍尔德菌-1-1-47 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ASD组 | 1.636 | 3.699 | 0.002 | 0.290 | 0.679 | 0.025 | 0.032 | 0.028 | 1.665 | 0.095 | |||
正常对照组 | 0.150 | 1.686 | 0.006 | 0.037 | 0.187 | 0.004 | 0.557 | 0.007 | 0.681 | 0.037 | |||
统计值 | 915.0 | 849.0 | 415.0 | 811.0 | 821.0 | 784.0 | 452.0 | 786.5 | 814.0 | 802.0 | |||
P值 | 0.000 2 | 0.005 | 0.008 | 0.009 | 0.011 | 0.013 | 0.014 | 0.016 | 0.017 | 0.018 | |||
组别 | 单形巨单胞菌 | Gordonibacter pamelaeae | 粪副 拟杆菌 | 生黄瘤 胃球菌 | 莫氏细小杆菌 | 毛螺科菌_3_1_ 57FAA_CT1 | Parasutterella excrementihominis | 直肠 真杆菌 | Candidate division_TM7_single_cell_isolate_TM7c | 麻疹孪生球菌 | |||
ASD组 | 0.212 | 0.018 | 1.068 | 0.008 0 | 0.001 | 0.045 | 0.139 | 2.549 | 0.001 | 0.000 3 | |||
正常对照组 | 0.120 | 0.007 | 0.886 | 0.000 3 | 0.002 | 0.011 | 0.049 | 5.018 | 0.006 | 0.004 0 | |||
统计值 | 785.0 | 800.0 | 807.5 | 737.0 | 469.5 | 780.5 | 793.0 | 794.0 | 488.0 | 488.0 | |||
P值 | 0.019 | 0.020 | 0.020 | 0.021 | 0.023 | 0.026 | 0.030 | 0.032 | 0.032 | 0.032 |
组别 | 翁德顿氏 另枝菌 | Alistipes putredinis | 毗邻颗粒链球菌 | 芬戈尔德氏拟杆菌 | 谢氏另 枝菌 | 前庭链球菌 | 死亡梭杆菌 | 丝状霍尔德曼菌 | 芽胞拟杆菌 | 伯克霍尔德菌-1-1-47 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ASD组 | 1.636 | 3.699 | 0.002 | 0.290 | 0.679 | 0.025 | 0.032 | 0.028 | 1.665 | 0.095 | |||
正常对照组 | 0.150 | 1.686 | 0.006 | 0.037 | 0.187 | 0.004 | 0.557 | 0.007 | 0.681 | 0.037 | |||
统计值 | 915.0 | 849.0 | 415.0 | 811.0 | 821.0 | 784.0 | 452.0 | 786.5 | 814.0 | 802.0 | |||
P值 | 0.000 2 | 0.005 | 0.008 | 0.009 | 0.011 | 0.013 | 0.014 | 0.016 | 0.017 | 0.018 | |||
组别 | 单形巨单胞菌 | Gordonibacter pamelaeae | 粪副 拟杆菌 | 生黄瘤 胃球菌 | 莫氏细小杆菌 | 毛螺科菌_3_1_ 57FAA_CT1 | Parasutterella excrementihominis | 直肠 真杆菌 | Candidate division_TM7_single_cell_isolate_TM7c | 麻疹孪生球菌 | |||
ASD组 | 0.212 | 0.018 | 1.068 | 0.008 0 | 0.001 | 0.045 | 0.139 | 2.549 | 0.001 | 0.000 3 | |||
正常对照组 | 0.120 | 0.007 | 0.886 | 0.000 3 | 0.002 | 0.011 | 0.049 | 5.018 | 0.006 | 0.004 0 | |||
统计值 | 785.0 | 800.0 | 807.5 | 737.0 | 469.5 | 780.5 | 793.0 | 794.0 | 488.0 | 488.0 | |||
P值 | 0.019 | 0.020 | 0.020 | 0.021 | 0.023 | 0.026 | 0.030 | 0.032 | 0.032 | 0.032 |
组别 | K08856 | K02319 | K04464 | K06322 | K09385 | K09628 | K09655 | K12444 | K12688 | K13003 |
---|---|---|---|---|---|---|---|---|---|---|
ASD组 | 9.257 | 90.714 | 20.571 | 50.829 | 22.600 | 15.257 | 38.200 | 78.343 | 4.429 | 24.514 |
正常对照组 | 109.657 | 1.000 | 7.457 | 4.571 | 1.771 | 5.257 | 7.543 | 11.143 | 62.257 | 2.257 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | K14446 | K14819 | K16323 | K17916 | K18563 | K18663 | K19562 | K20891 | K21285 | K21559 |
ASD组 | 21.429 | 46.457 | 23.543 | 30.200 | 21.829 | 1.971 | 1.143 | 23.886 | 35.800 | 60.286 |
正常对照组 | 4.629 | 4.171 | 4.371 | 91.114 | 1.600 | 17.743 | 178.400 | 1.343 | 2.743 | 17.829 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | K08856 | K02319 | K04464 | K06322 | K09385 | K09628 | K09655 | K12444 | K12688 | K13003 |
---|---|---|---|---|---|---|---|---|---|---|
ASD组 | 9.257 | 90.714 | 20.571 | 50.829 | 22.600 | 15.257 | 38.200 | 78.343 | 4.429 | 24.514 |
正常对照组 | 109.657 | 1.000 | 7.457 | 4.571 | 1.771 | 5.257 | 7.543 | 11.143 | 62.257 | 2.257 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | K14446 | K14819 | K16323 | K17916 | K18563 | K18663 | K19562 | K20891 | K21285 | K21559 |
ASD组 | 21.429 | 46.457 | 23.543 | 30.200 | 21.829 | 1.971 | 1.143 | 23.886 | 35.800 | 60.286 |
正常对照组 | 4.629 | 4.171 | 4.371 | 91.114 | 1.600 | 17.743 | 178.400 | 1.343 | 2.743 | 17.829 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | BAL 99265.1 | ADL 06029.1 | AAX 16429.1 | AGH 13967.1 | AGA 79657.1 | BAL 89591.1 | ACU 75803.1 | CBK 64070.1 | AFL 78142.1 | ADE 82788.1 |
---|---|---|---|---|---|---|---|---|---|---|
ASD组 | 73.50 | 6 284.12 | 966.02 | 1 055.22 | 679.79 | 535.12 | 347.88 | 945.90 | 392.42 | 1 534.98 |
正常对照组 | 15.27 | 2 546.19 | 140.75 | 957.69 | 137.98 | 48.49 | 24.89 | 277.44 | 64.19 | 1 094.22 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | ADC 62725.1 | BAK 99340.1 | AHV 36377.1 | CBK 63395.1 | AEV 68695.1 | AHI 40605.1 | AIB 13586.1 | AFL 77442.1 | CBK 65046.1 | AGB 29347.1 |
ASD组 | 343.52 | 894.97 | 451.41 | 170.82 | 537.58 | 512.26 | 1 247.12 | 831.97 | 731.97 | 1 771.90 |
正常对照组 | 122.14 | 294.08 | 71.32 | 44.77 | 368.44 | 117.46 | 1 020.04 | 251.46 | 229.29 | 1 109.50 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | BAL 99265.1 | ADL 06029.1 | AAX 16429.1 | AGH 13967.1 | AGA 79657.1 | BAL 89591.1 | ACU 75803.1 | CBK 64070.1 | AFL 78142.1 | ADE 82788.1 |
---|---|---|---|---|---|---|---|---|---|---|
ASD组 | 73.50 | 6 284.12 | 966.02 | 1 055.22 | 679.79 | 535.12 | 347.88 | 945.90 | 392.42 | 1 534.98 |
正常对照组 | 15.27 | 2 546.19 | 140.75 | 957.69 | 137.98 | 48.49 | 24.89 | 277.44 | 64.19 | 1 094.22 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
组别 | ADC 62725.1 | BAK 99340.1 | AHV 36377.1 | CBK 63395.1 | AEV 68695.1 | AHI 40605.1 | AIB 13586.1 | AFL 77442.1 | CBK 65046.1 | AGB 29347.1 |
ASD组 | 343.52 | 894.97 | 451.41 | 170.82 | 537.58 | 512.26 | 1 247.12 | 831.97 | 731.97 | 1 771.90 |
正常对照组 | 122.14 | 294.08 | 71.32 | 44.77 | 368.44 | 117.46 | 1 020.04 | 251.46 | 229.29 | 1 109.50 |
P值 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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