Abstract:

Objective To investigate the relationship between plasma Nesfatin-1,Dickkopf-1（DKK-1） and osteonecrosis of the femoral head（ONFH）. Methods A total of 85 patients with ONFH（ONFH group） and 50 healthy subjects（control group） were enrolled. The levels of plasma Nesfatin-1 and DKK-1 were determined. Spearman rank correlation analysis was used to evaluate the correlation between Nesfatin-1,DKK-1 and the Association Research Circulation Osseous（ARCO）staging. Receiver operating characteristic（ROC） curve was used to evaluate the efficiency of each index in the diagnosis of femoral head collapse. Results The plasma levels of Nesfatin-1 and DKK-1 in ONFH group were higher than those in control group（P<0.05）. The plasma levels of Nesfatin-1 and DKK-1 in ONFH group increased with the increase of ARCO staging（P<0.05）. The plasma levels of Nesfatin-1 and DKK-1 in patients with femoral head collapse were higher than those without femoral head collapse（P<0.05）. Spearman rank correlation analysis results showed that plasma Nesfatin-1 and DKK-1 levels were positively correlated with ARCO staging（r_s=0.733 and 0.626,P<0.05）. ROC curve analysis showed that the areas under curves（AUC）of Nesfatin-1,DKK-1 single and combined determinations in the diagnosis of femoral head collapse were 0.707,0.643 and 0.889,respectively. Conclusions The plasma Nesfatin-1 and DKK-1 levels are related to ONFH.

Key words: Nesfatin-1, Dickkopf-1, Osteonecrosis of the femoral head