Relationship between serum AMH,FSH,InhB and sperm parameters

doi:10.3969/j.issn.1673-8640.2021.010.012

Abstract

Abstract:

Objective To analyze the relationship between serum anti-Müllerian hormone（AMH）,follicle-stimulating hormone（FSH） and inhibin B（InhB）and sperm parameters,and to investigate the roles of serum AMH,FSH and InhB in the diagnosis of male infertility. Methods According to the results of sperm parameters and testicular biopsy,97 patients were classified into obstructive azoospermia（15 cases）,non-obstructive azoospermia（12 cases） and oligoasthenospermia（70 cases）,and 122 males with qualified semen quality were enrolled as control group. The total sperm count,sperm concentration,sperm motility,forward movement sperm rate and serum AMH,FSH and InhB were analyzed for their correlations. Results Compared with control group and obstructive azoospermia group,serum levels of AMH,FSH and InhB in non-obstructive azoospermia and oligoasthenospermia had statistical significance（P<0.05）. AMH was positively correlated with total sperm count,sperm concentration,sperm motility and forward movement sperm rate（r=0.227,0.215,0.111 and 0.120,P<0.05）. FSH was negatively correlated with total sperm count and sperm concentration（r=-0.125 and -0.236,P<0.05）. There were positive correlations between InhB and total sperm count,sperm concentration（r=0.232 and 0.166,P<0.05）. Conclusions The determinations of serum AMH,FSH and InhB can provide a reference for the diagnosis and treatment of male infertility.

Key words: Anti-Müllerian hormone;, Inhibin B, Follicle-stimulating hormone, Sperm parameter, Obstructive azoospermia, Non-obstructive azoospermia

CLC Number:

R446.69

LIU Xiuju, LI Gaochi, YANG Hongmei, LIN Jianchun. Relationship between serum AMH,FSH,InhB and sperm parameters[J]. Laboratory Medicine, 2021, 36(10): 1047-1049.

Figures/Tables 2

References 15

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组别	例数	AMH/（ng/mL）	FSH/（U/L）	InhB/（ng/mL）
梗阻性无精子症组	15	8.91±3.75	4.21±2.15	135.65±41.25
非梗阻性无精子症组	12	6.23±2.95^*	5.94±2.55^*	86.54±27.65^*
少弱精子症组	70	7.45±3.14^*	5.26±2.98^*	95.39±31.45^*
对照组	122	9.13±3.15	4.15±2.37	157.76±57.23

组别	例数	AMH/（ng/mL）	FSH/（U/L）	InhB/（ng/mL）
梗阻性无精子症组	15	8.91±3.75	4.21±2.15	135.65±41.25
非梗阻性无精子症组	12	6.23±2.95^*	5.94±2.55^*	86.54±27.65^*
少弱精子症组	70	7.45±3.14^*	5.26±2.98^*	95.39±31.45^*
对照组	122	9.13±3.15	4.15±2.37	157.76±57.23

项目	精子总数		精子浓度		精子活力		前向运动精子百分率
项目	r值	P值	r值	P值	r值	P值	r值	P值
AMH	0.227	0.026	0.215	0.037	0.111	0.012	0.120	0.022
FSH	-0.125	0.031	-0.236	0.015	-0.008	0.072	-0.060	0.122
InhB	0.232	0.028	0.166	0.035	0.025	0.102	0.020	0.252

项目	精子总数		精子浓度		精子活力		前向运动精子百分率
项目	r值	P值	r值	P值	r值	P值	r值	P值
AMH	0.227	0.026	0.215	0.037	0.111	0.012	0.120	0.022
FSH	-0.125	0.031	-0.236	0.015	-0.008	0.072	-0.060	0.122
InhB	0.232	0.028	0.166	0.035	0.025	0.102	0.020	0.252