Research progress of macrolide-resistant Mycoplasma pneumoniae

doi:10.3969/j.issn.1673-8640.2020.10.024

Abstract

Abstract:

Mycoplasma pneumoniae（MP） is one of the predominant pathogens causing community-acquired pneumonia（CAP）. In recent years,the prevalence of macrolide-resistant Mycoplasma pneumoniae（MRMP） has rapidly increased in worldwide. MRMP was highly prevalent in Asia,especially in China,South Korea and Japan,while the prevalence is relatively low in North America,Europe and Africa. The resistance mechanism of MP mainly dues to the mutation of 23S rRNA gene. The single point mutation in the 23S rRNA gene is the main macrolide resistance mechanism of MRMP,which can reduce the affinity of macrolide antibiotics with ribosomes and then develop resistance.. The positive rate of MRMP P1-I or MLVA4-5-7-2 is higher than other types. The key for controlling the infection of MP is rapid diagnosis and rational use of antibiotics. Although there are several rapid determination methods reported,they do not have a uniform standard, and also not routinely used in clinical practice. It is still necessary to explore the most suitable rapid detection method for MP.

Key words: Mycoplasma pneumonia, Macrolide resistance, Laboratory determination

CLC Number:

R375

WANG Bingjie, ZHANG Hong. Research progress of macrolide-resistant Mycoplasma pneumoniae[J]. Laboratory Medicine, 2020, 35(10): 1070-1074.

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