Abstract:

Objective To investigate the distribution characteristics of allergen spectrum for food intolerance children in Shanghai,and to provide a reference for the prevention and treatment of food intolerance disease. Methods A total of 2 437 children with food intolerance received allergen test. Enzyme-linked immunosorbent assay（ELISA） was used for determining serum food specific IgG antibody,and the results were analyzed statistically. Results Among the 2 437 patients,serum food specific IgG antibody was positive in 1 928 cases（79.1%）. The main allergen was egg white/yolk,whose positive rate was 54.7%,followed by wheat （44.3%）,tomato（31.3%） and milk （30.5%）. Pork and beef were allergens with low positive rates（<1%）. The positive rate of egg white/yolk in boys was higher than that in girls,while the positive rate of mushroom in girls was higher than that in boys（P<0.05）. There was statistical significance in milk,egg white/yolk,wheat,corn,cod,rice,tomato,crab,shrimp and chicken among children with different ages（P<0.05）. With the increasing of age,the positive rates of serum food specific IgG antibody for some allergens were decreased. Conclusions Egg white/yolk,wheat,tomato and milk are main allergens for child food intolerance disease in Shanghai. The allergen test can determine allergens,and it plays a role in individualized treatment and health education for children with food intolerance disease.

Key words: Allergen, Anaphylactic reaction, Specific IgG antibody, Food intolerance