Serum food-specific IgG and specific IgG4 in 655 patients with chronic urticaria

doi:10.3969/j.issn.1673-8640.2017.09.007

Abstract

Abstract:

Objective To determine serum food-specific IgG（sIgG）and specific IgG4（sIgG4）in patients with chronic urticaria,to analyze the correlations of the levels of sIgG and sIgG4 with the disease severity of urticaria and life quality,and to evaluate the clinical outcome of dietary avoidance after 6 months.Methods Enzyme-linked immunosorbent assay（ELISA） was used to determine the levels of sIgG and sIgG4 against 20 kinds of food in 655 patients with chronic urticaria and 51 healthy subjects（healthy control group）. The Weekly Urticaria Activity Score（UAS7）,the Dermatology Life Quality Index（DLQI）and oral antihistamine dosage were evaluated by questionnaires for 65 patients selected randomly. The clinical outcome of dietary avoidance was evaluated after 6 months in 26 patients. Results The positive rates of sIgG and sIgG4 were higher in chronic urticaria patients（74.4% and 69.3%） than in healthy control group（13.7% and 5.9%）（P<0.01）. Egg,peanut,milk,soya bean and crab were the most common food with high positive rates. There was no correlation of the levels of sIgG and sIgG4 with UAS7,DLQI and oral antihistamine dosage. There was statistical significance for UAST,DLQI and oral antihistamine dosage before and after dietary avoidance（P<0.01）.Conclusionss The determinations of sIgG and sIgG4 may be helpful for the etiologic diagnosis and treatment of chronic urticaria.

Key words: Specific IgG, Specific IgG4, Chronic urticaria, Food adverse reaction

CLC Number:

R446.62

WANG Xinxin, WU Shandong, CHENG Hao, ZHU Kejian. Serum food-specific IgG and specific IgG4 in 655 patients with chronic urticaria[J]. Laboratory Medicine, 2017, 32(9): 773-778.

Figures/Tables 8

References 19

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评分	风团	瘙痒
0	无	无
1	轻度（<20个风团/24 h）	轻度（有瘙痒,但不引起患者的烦恼）
2	中度（20~50个风团/24 h）	中度（引起患者的烦恼,但尚未影响患者的日常活动和睡眠）
3	重度（>50个风团/24 h或大片融合）	重度（影响患者的日常活动和睡眠）

评分	风团	瘙痒
0	无	无
1	轻度（<20个风团/24 h）	轻度（有瘙痒,但不引起患者的烦恼）
2	中度（20~50个风团/24 h）	中度（引起患者的烦恼,但尚未影响患者的日常活动和睡眠）
3	重度（>50个风团/24 h或大片融合）	重度（影响患者的日常活动和睡眠）

组别	引起sIgG升高的食物项目					引起sIgG4升高的食物项目
组别	0项	1项	2项	3项	≥4项	0项	1项	2项	3项	≥4项
患者组	25.7	34.1	15.4	10.7	14.2	30.7	32.5	13.6	10.2	13.0
对照组	86.3	13.7	0.0	0.0	0.0	94.1	5.9	0.0	0.0	0.0

组别	引起sIgG升高的食物项目					引起sIgG4升高的食物项目
组别	0项	1项	2项	3项	≥4项	0项	1项	2项	3项	≥4项
患者组	25.7	34.1	15.4	10.7	14.2	30.7	32.5	13.6	10.2	13.0
对照组	86.3	13.7	0.0	0.0	0.0	94.1	5.9	0.0	0.0	0.0

组别	过敏原
组别	菠萝	鸡蛋	鸡肉	牛奶	虾	小麦
A组	12.91 （0.39,339.00）	66.20 （0.63,499.05）	14.28 （1.08,152.41）	15.17 （1.76,145.47）	15.17 （1.76,145.47）	15.77 （3.15,285.99）
B组	13.39 （0.00,169.26）	37.33 （1.62,594.42）	13.11 （0.18,400.00）	8.19 （0.28,400.00）	19.74 （2.77,189.04）	13.98 （0.00,354.05）
C组	16.57 （1.48,400.00）	21.72 （0.49,400.00）	15.56 （3.07,89.51）	6.88 （0.53,160.23）	21.83 （3.22,158.06）	14.37 （2.33,79.96）
P值	0.031	0.000	0.035	0.000	0.000	0.029