MicroRNA-1246 in patients with breast cancer

doi:10.3969/j.issn.1673-8640.2017.07.007

Abstract

Abstract:

Objective To analyze the expression of microRNA（miRNA）-1246 in sera and tissues among breast cancer patients,and to investigate the role of serum miRNA-1246 in the diagnosis of breast cancer. Methods Fluorescence quantitation polymerase chain reaction （PCR） was used to determine the expression of miRNA-1246 in sera of 100 breast cancer patients and 40 healthy controls,in 30 cases of breast cancer tissues and 15 cases of breast cancer adjacent tissues. Results The expression of miRNA-1246 was higher in sera of breast cancer patients than that in sera of healthy controls （P<0.05）. There was no statistical significance for miRNA-1246 expression between breast cancer tissues and breast cancer adjacent tissues （P>0.05）. Serum miRNA-1246 had an area under receiver operating characteristic（ROC） curve of 0.904,with sensitivity of 93% and specificity of 75%. Conclusions Serum miRNA-1246 shows good sensitivity and specificity for diagnosing breast cancer,and can be used as a potential tumor marker.

Key words: MicroRNA-1246, Breast cancer, In vitro and in vivo

CLC Number:

R446.1

WANG Pan, ZHU Jie, GU Wanhong, LI Zhaoyun. MicroRNA-1246 in patients with breast cancer[J]. Laboratory Medicine, 2017, 32(7): 586-589.

Figures/Tables 2

References 16

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