Research progress of antiplatelet drug

doi:10.3969/j.issn.1673-8640.2015.12.022

Abstract

Abstract:

Despite the development of new antiplatelet agents,aspirin and clopidogrel dual antiplatelet therapy still has a major role in the prevention of stent thrombosis and ischemic events. However, a considerable number of patients in treatment with standard dual antiplatelet therapy continue to have cardiovascular events. This has been,in part,attributed to the fact that some patients may have poor antiplatelet effects. This phenomenon has caused considerable attention. Recently, a lot of researches on this phenomenon have appeared. However, these studies have some limitations, such as, the difference of platelet function tests, high inter-individual variability of antiplatelet agents and some other diseases affecting antiplatelet drug. In this review, we mainly discuss in vitro platelet function tests,genetic polymorphisms and some clinical disease interference with antiplatelet agents to elaborate the relationship between the reason of interference with antiplatelet agents and ischemic events.

Key words: Antiplatelet drug, Nonresponder, Platelet activity, Genetic polymorphism

CLC Number:

R446.11

CUI Chanjuan, QIAO Rui, ZHANG Jie.. Research progress of antiplatelet drug "nonresponder"[J]. Laboratory Medicine, 2015, 30(12): 1257-1262.

Figures/Tables 4

References 40

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等位基因	高加索人	非洲裔美国人	亚洲人
^*2	28	21	50
^*3	<1	<1	18
^*17	33	29	6

等位基因	高加索人	非洲裔美国人	亚洲人
^*2	28	21	50
^*3	<1	<1	18
^*17	33	29	6