Research on lysyl oxidase and pelvic organ prolapse

doi:10.3969/j.issn.1673-8640.2014.11.026

›› 2014, Vol. 29 ›› Issue (11): 1191-1194.DOI: 10.3969/j.issn.1673-8640.2014.11.026

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Research on lysyl oxidase and pelvic organ prolapse

WU Huiheng¹, CHEN Xinliang², TONG Xiaowen¹

1.Department of Gynaecology and Obstetrics, Tongji Hospital, Tongji University, Shanghai 200065, China;
2. Department of Gynaecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200019, China

Received:2014-04-09 Online:2014-11-01 Published:2014-11-28
Contact: 童晓文,联系电话:021-66111054。

Abstract

Abstract: Pelvic organ prolapse (POP) is a common gynecopathy, but the pathogenesis of POP is obscure up to now. Recent studies have shown an association between POP and the destroy of structural and functional integrity of pelvic connective tissue. The main proteins composing pelvic connective tissue extracellular matrix (ECM) are elastin and collagen. Elastin and collagen contents and structural changes can cause the decreasing of tissue elasticity and the relaxation of pelvic floor structure. Lysyl oxidase (LOX) can catalyze the polymerization of elastic fibers forming covalent crosslinking to increase the stability of EMC, so it is supposed that the change of LOX expression may make a certain contribution to the occurrence and development of POP.

Key words: Lysyl oxidase, Pelvic organ prolapse, Elastic fiber, Elastin

CLC Number:

R446.1

WU Huiheng, CHEN Xinliang, TONG Xiaowen. Research on lysyl oxidase and pelvic organ prolapse[J]. , 2014, 29(11): 1191-1194.

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Research on lysyl oxidase and pelvic organ prolapse

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