Abstract:

Objective　To verify the validity of maternal weight adjustment, and to study the influence of maternal weight adjustment on second trimester prenatal triple marker screening in the Obstetrics and Gynecology Hospital of Fudan University. Methods　A total of 28 577 second trimester pregnant women were enrolled, and their serum samples were determined by chemiluminescence immunoassay for Down syndrome second trimester prenatal screening with triple markers, alpha fetoprotein (AFP), beta subunit of human chorionic gonadotropin (β-hCG) and unconjugated estriol (uE3). After regressing the maternal weight adjustment parameters, the MoM of maternal weight adjustment was obtained, and the risks of Down syndrome, Edward syndrome and open neural tube disease were calculated. Results　Reciprocal-linear was the best fitting model. The reciprocal-linear model detected 2 cases of Down syndrome, thus the detection rate increased from 65% to 76%, comparing to that of no maternal weight adjustment. Conclusions　 Maternal weight adjustment can increase the detection rate of Down syndrome as well as diminish the influence of maternal weight on serum marker concentrations. Every laboratory should establish a laboratory-specific maternal weight adjustment to report accurate risk assessment for Down syndrome, Edward syndrome and open neural tube disease.

Key words: Down syndrome, Prenatal screening, Weight adjustment, MoM