Abstract:

Objective　To study the expressions of Survivin and c-myc in renal cell carcinoma tissue and their clinical significance. Methods　By reverse transcription polymerase chain reaction（RT-PCR） and Western-blot， the expressions of Survivin and c-myc were determined in 34 renal cell carcinoma specimens. The relationship of the 2 genes and clinical pathological characteristics were analyzed. Results　The expressions of Survivin and c-myc in renal cell carcinoma tissue were higher than those in normal tissues with statistical significance（P＜0.01）. The expression of Survivin was significantly related to the clinical stage and lymphonode metastasis（P＜0.05）. The expression of c-myc was significantly related to the degrees of pathological differentiation（P＜0.05）.The expression of Survivin in renal cell carcinoma tissue was positively related to the expression of c-myc（r=0.446， P＜0.01）. Conclusions　The overexpression of Survivin and c-myc could have important roles in the carcinogenesis and development of renal cell carcinoma.

Key words: Survivin, c-myc, Renal cell carcinoma