The research progress in the molecular diagnosis of blood stream infection

doi:10.3969/j.issn.1673-8640.2014.06.002

Abstract

Abstract:

The blood stream infection is a syndrome of serious systemic infection, and blood culture remains being the gold standard for the diagnosis of bacterial blood stream infection, but only 30%-40% blood stream infection pathogens could be found by blood culture. Molecular biology method through analyzing the nucleic acid of microorganisms in blood samples will quickly provide the results of bacterial, fungal or viral infections accurately, and provide a common resistance gene detection results of pathogens. At present, the molecular diagnosis techniques for blood stream infection in clinical laboratoriesmainly include nucleic acid hybridization, nucleic acid amplification and DNA sequence analysis, gene chip, mass spectrometry and so on. The common pathogenic bacteria, mycobacteria, fastidious bacteria, rare pathogenic bacteria use a variety of detection techniques combined with the application of rapid identification and drug resistance analysis, which can provide reliable diagnosis results for clinical in a relatively short period of time, indicate the use of clinical rational drug and improve survival in patients with blood stream infection.

Key words: Blood stream infection, Molecular diagnosis, Research progress

CLC Number:

R446.5

GUO Jian,WU Wenjuan. The research progress in the molecular diagnosis of blood stream infection[J]. , 2014, 29(6): 584-589.

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