Clinical significance of monitoring BK virus in transplanting patients

doi:10.3969/j.issn.1673-8640.2014.05.015

Abstract

Abstract: Objective To monitor blood and urine BK virus (BKV) load and discuss the influence of sex, age, human cytomegalovirus(HCMV) and immunosuppressor on BKV load and the influence of BKV load on diseases. Methods BKV loads of plasma and urine from patients were measured by real-time fluorescence quantitation polymerase chain reaction(PCR). The influence of plasma HCMV concentration and immunosuppressor concentrantion on BKV load and the influence of high or low BKV load on diseases were analyzed. Results BKV was detected in 242 (12.1%) cases of 1 985 patients with or without transplantation. A total of 211 cases were positive in plasma (10.6%), while 118 cases were positive in urine (5.9%). Bone marrow transplantation, kidney transplantation and none transplantation patients had different BKV positive rates with statistical significance (P<0.01). Almost all cases of BKV positive occurred in the first 3 months after transplantation. There was no statistical significance between HCMV infection and BKV load (P=0.272 9). Among bone marrow transplantation and kidney transplantation patients, the differences of BKV load to plasma immunosuppessor concentration and cyclosporine A(CsA) concentration (>150 ng/mL) had statistical significance (P<0.01), those to tacrolimus (FK506)(>8.0 mg/mL) had no statistical significance (P=0.278 5). For BKV positive and negative patients, there was statistical significance when monitoring serum creatinine (CREA)(P=0.020 7). Conclusions There is no relationship of sex, age and concurrent infection of HCMV infection with BKV replication. However, the concentration of plasma immunosuppressor is related with BKV replication. The secondary damage can be reduced by adjusting the dose of immunosuppressor from continuously monitoring BKV load.

Key words: BK virus, Transplantation, Immunosuppressor

CLC Number:

R373.9

WU Beiying, CAI Gang, LIN Jiafei, FAN Zhenjia, FAN Qishi.. Clinical significance of monitoring BK virus in transplanting patients[J]. , 2014, 29(5): 493-498.

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