Development of warfarin-related pharmacogenomics and its prospect of clinical application

doi:10.3969/j.issn.1673-8640.2014.03.003

Abstract

Abstract:

Warfarin,a commonly prescribed anticoagulant,has warried lots of patients and doctors because of its narrow therapeutic range and large interindividual variability in daily dose. During recent years,many studies focus on genetic polymorphisms,regarding it as one of the main effects which lead to dose difference between individuals. Some of them established and verified pharmacogenetic-based warfarin-dosing algorithms and evaluated the clinical significance. Our review exhibits the latest development of warfarin-related pharmacogenomics home and abroad,in order to provide references for further clinical studies.

Key words: Warfarin, Pharmacogenomics, Clinical application

CLC Number:

Q503

WU Jiong, WU Shengchao, GUO Wei, PAN Baishen.. Development of warfarin-related pharmacogenomics and its prospect of clinical application[J]. , 2014, 29(3): 209-214.

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