The significance of IGF-1 and IGFBP-3 in the diagnosis of gastric cancer

doi:10.3969/j.issn.1673-8640.2013.05.011

Abstract

Abstract: Objective　To evaluate the clinical significance of serum insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) in the diagnosis of gastric cancer and gastric precancerous lesion. Methods　The serum levels of IGF-1，IGFBP-3，carcinoembryonic antigen (CEA) and carbohydrate antigen 199(CA199) were measured by chemiluminescence immunoassay，enzyme-linked immunosorbent assay(ELISA) and electro-chemiluminescence immunoassay in 90 patients with gastric cancer，40 patients with gastric benign disease and 50 healthy subjects. Results　The serum levels of IGF-1 in patients with gastric cancer were significantly higher than those in patients with gastric benign disease and healthy subjects（P＜0.05，P＜0.001）. The serum levels of IGFBP-3 in patients with gastric cancer were significantly lower than those in patients with gastric benign disease and healthy subjects(P＜0.001).The serum levels of IGF-1 in the early (Ⅰ-Ⅱ) stage of gastric cancer were lower than those in the late (Ⅲ-Ⅳ) stage， but were higher than those in the healthy subjects，and the serum levels of IGFBP-3 were higher than those in the late stage， but were lower than those in the healthy subjects.The serum levels of IGF-1 had significantly negative correlation with IGFBP-3，and the linear correlation equation was Y =-0.33X +116.65(r=-0.566，P＜0.01). There was no correlation between IGF-1 and IGFBP-3 with CEA and CA199. Using the healthy subjects as controls，the areas under the receiver operating characteristic(ROC) curve (AUC) of IGF-1 was obviously higher than those of CEA and CA199(P＜0.01，P＜0.05). The sensitivity of IGF-1 for the diagnosis of gastric cancer was higher than those of CEA and CA199(P＜0.05). Conclusions　IGF-1 is better than CEA and CA199， in the diagnosis of gastric cancer，and it is helpful for the evaluation of gastric cancer stages.

Key words: Insulin-like growth factor-1, Insulin-like growth factor binding protein-3, Gastric cancer, Gastric precancerous lesion

PENG Chong，SUN Guirong，ZHANG Nana，GAO Zhenliang，Lü Xiaoyu. The significance of IGF-1 and IGFBP-3 in the diagnosis of gastric cancer[J]. , 2013, 28(5): 391-395.

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