血液中组织因子的分布及其与各种血细胞的关系

检验医学 ›› 2012, Vol. 27 ›› Issue (9): 780-783.

血液中组织因子的分布及其与各种血细胞的关系

刘长营¹,王丕明¹,许振宗¹,李海²

1. 武警山东省总队医院检验科，山东济南 250014；2. 武警日照市支队卫生队，山东日照 276800

收稿日期:2012-07-09 修回日期:2012-08-31 出版日期:2012-09-12 发布日期:2012-09-12
作者简介:刘长营，男，1982年生，硕士，技师，主要从事临床检验工作和免疫学研究。

Received:2012-07-09 Revised:2012-08-31 Online:2012-09-12 Published:2012-09-12

摘要/Abstract

摘要： 组织因子(tissue factor)是由263个氨基酸残基组成的跨膜单链糖蛋白，相对分子质量约为47 000。其中氨基端219个氨基酸残基位于细胞膜外，紧随其后的23个氨基酸残基穿过细胞膜，其余21个氨基酸残基位于细胞质内。组织因子通过与因子Ⅶ/ Ⅶa结合启动血液凝固级联反应；另外，组织因子可同时激活凝血因子Ⅸ和Ⅹ，启动内源性和外源性凝血酶联放大反应，在血栓形成过程中起着重要作用。通常认为，组织因子在血管壁外膜细胞，包绕血管的成纤维细胞，肝、脾、肾等器官的纤维囊，皮肤外层的表皮细胞，肾小球上皮细胞，脑皮质，心肌细胞，肺泡巨噬细胞，胃肠道壁，部分泌尿生殖道和子宫内膜基质细胞中均有分布，而在血管中膜或内膜层却很稀少。因此认为在正常情况下组织因子不存在于循环血液中或不与循环血接触，只有当血管壁的完整性遭到破坏时组织因子才暴露于循环血液，通过激活凝固级联反应发挥止血作用。然而，这一观点在最近的一系列研究中受到了质疑，有研究认为在适当条件下一些血细胞也可以合成并表达组织因子。我们就循环血液中组织因子的表达及组织因子与各种血细胞的关系做如下综述。

刘长营;王丕明;许振宗;李　海. 血液中组织因子的分布及其与各种血细胞的关系[J]. 检验医学, 2012, 27(9): 780-783.

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