CCCTC结合因子在中枢神经系统疾病中的作用研究进展

doi:10.3969/j.issn.1673-8640.2026.01.017

摘要/Abstract

摘要：

CCCTC结合因子（CTCF）是一种在生物体中普遍表达的多功能转录因子，含有特殊的11-锌指结构，能够与DNA序列或蛋白质结合，参与基因的表达调控。CTCF作为染色质拓扑结构的中心调节因子，参与调节神经元细胞分化、神经炎症和突触功能，与阿尔茨海默病（AD）、帕金森病（PD）和神经胶质瘤密切相关。文章就CTCF在中枢神经系统疾病中的作用进行综述，以期了解中枢神经系统疾病的发病机制，提供潜在的临床治疗靶点。

关键词: CCCTC结合因子, 阿尔茨海默病, 帕金森病, 神经胶质瘤

Abstract:

CCCTC-binding factor （CTCF） is a ubiquitous transcription factor expressed in organisms，containing a special 11-zinc finger structure that can bind to DNA sequences or proteins，and participates in the regulation of gene expression. As a central regulator of chromatin topology，CTCF is involved in regulating neuronal cell differentiation，neuroinflammation and synaptic function，and is related to Alzheimer's disease（AD），Parkinson's disease（PD）and glioma. This review focuses on the role of CTCF in central nervous system diseases，in order to understand the pathogenesis of central nervous system diseases and provide potential clinical therapeutic targets.

Key words: CCCTC-binding factor, Alzheimer's disease, Parkinson's disease, Glioma

中图分类号:

R446.1

高硕, 王培昌, 侯玉丽. CCCTC结合因子在中枢神经系统疾病中的作用研究进展[J]. 检验医学, 2026, 41(1): 95-100.

GAO Shuo, WANG Peichang, HOU Yuli. Research progress of CCCTC-binding factor in central nervous system diseases[J]. Laboratory Medicine, 2026, 41(1): 95-100.

图/表 1

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