房水基质金属蛋白酶-3在青光眼亚型鉴别诊断中的价值

doi:10.3969/j.issn.1673-8640.2026.07.001

检验医学 ›› 2026, Vol. 41 ›› Issue (7): 621-624.DOI: 10.3969/j.issn.1673-8640.2026.07.001

• 论著 • 下一篇

房水基质金属蛋白酶-3在青光眼亚型鉴别诊断中的价值

丁雪晴¹, 刘玉¹, 滕济森¹, 曹文俊¹, 孔祥梅², 王朱健¹()

¹ 复旦大学附属眼耳鼻喉科医院检验科，上海 200031
² 复旦大学附属眼耳鼻喉科医院眼科，上海 200031

收稿日期:2025-12-24 修回日期:2026-05-12 出版日期:2026-07-30 发布日期:2026-07-23
通讯作者: 王朱健，E-mail：18917785189@163.com。
作者简介:丁雪晴，女，1999年生，学士，检验技师，主要从事临床检验工作。
基金资助:
国家自然科学基金项目(82070957)

Role of aqueous humor matrix metalloproteinase-3 in the differential diagnosis of glaucoma subtypes

DING Xueqing¹, LIU Yu¹, TENG Jisen¹, CAO Wenjun¹, KONG Xiangmei², WANG Zhujian¹()

¹ Department of Clinical Laboratory， Eye & ENT Hospital，Fudan University， Shanghai 200031， China
² Department of Ophthalmology， Eye & ENT Hospital，Fudan University， Shanghai 200031， China

Received:2025-12-24 Revised:2026-05-12 Online:2026-07-30 Published:2026-07-23

摘要/Abstract

摘要：

目的探讨不同亚型青光眼患者房水基质金属蛋白酶（MMP）-3水平的差异，及其在青光眼睫状体炎综合征（PSS）和原发性开角型青光眼（POAG）鉴别诊断中的价值。方法选取2024年1月—2025年6月复旦大学附属眼耳鼻喉科医院青光眼患者100例，包括PSS 37例（PSS组）、POAG 32例（POAG组）、闭角型青光眼（ACG）31例（ACG组），以年龄相关性白内障（ARC）患者25例作为对照组。检测所有患者的眼压和房水MMP-3水平。采用Spearman相关分析评估房水MMP-3水平与眼压的相关性。采用受试者工作特征（ROC）曲线评价房水MMP-3鉴别诊断PSS和POAG的效能。结果 PSS组和ACG组房水MMP-3水平显著高于对照组和POAG组（P<0.000 1），PSS组和ACG组之间差异无统计学意义（P>0.05）。PSS组、POAG组和ACG组房水MMP-3水平均与眼压无相关性（r值分别为-0.125、0.271、0.180，P>0.05）。房水MMP-3鉴别诊断PSS和POAG的曲线下面积（AUC）为0.821。结论房水MMP-3可作为鉴别诊断PSS和POAG的生物标志物。

关键词: 基质金属蛋白酶-3, 房水, 青光眼

Abstract:

Objective To investigate the differences in aqueous humor matrix metalloproteinase（MMP）-3 levels among different subtypes of glaucoma patients and its value in the differential diagnosis of primary open-angle glaucoma（POAG）and Posner-Schlossman syndrome（PSS）. Methods A total of 100 glaucoma patients from Eye & ENT Hospital of Fudan University from January 2024 to June 2025 were enrolled，including 37 cases of PSS（PSS group），32 cases of POAG（POAG group） and 31 cases of angle-closure glaucoma （ACG）（ACG group），with 25 cases of age-related cataract（ARC）as control group. The intraocular pressure and aqueous humor MMP-3 levels were determined. Spearman correlation analysis was used to evaluate the correlation between aqueous humor MMP-3 levels and intraocular pressure. Receiver operating characteristic（ROC）curve was used to evaluate the efficacy of aqueous humor MMP-3 in differentiating PSS and POAG. Results The aqueous humor MMP-3 levels in PSS group and ACG group were higher than those in control group and POAG group（P<0.000 1），and there was no statistical significance between PSS group and ACG group（P>0.05）. There was no correlation between aqueous humor MMP-3 levels and intraocular pressure in PSS group，POAG group and ACG group（r values were -0.125，0.271 and 0.180，respectively，P>0.05）. The area under curve（AUC）for aqueous humor MMP-3 in differentiating PSS and POAG was 0.821. Conclusions Aqueous humor MMP-3 can be a biomarker for differentiating PSS and POAG.

Key words: Matrix metalloproteinase-3, Aqueous humor, Glaucoma

中图分类号:

R446.1

丁雪晴, 刘玉, 滕济森, 曹文俊, 孔祥梅, 王朱健. 房水基质金属蛋白酶-3在青光眼亚型鉴别诊断中的价值[J]. 检验医学, 2026, 41(7): 621-624.

DING Xueqing, LIU Yu, TENG Jisen, CAO Wenjun, KONG Xiangmei, WANG Zhujian. Role of aqueous humor matrix metalloproteinase-3 in the differential diagnosis of glaucoma subtypes[J]. Laboratory Medicine, 2026, 41(7): 621-624.

图/表 3

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组别	例数	MMP-3/（ng·mL^-1）
PSS组	37	19.2（10.2，31.3）^*#
POAG组	32	3.2（0.0，11.4）
ACG组	31	17.7（6.2，45.4）^*#
对照组	25	4.7（0.8，7.1）
H值		36.797 8
P值		<0.000 1

组别	例数	MMP-3/（ng·mL^-1）
PSS组	37	19.2（10.2，31.3）^*#
POAG组	32	3.2（0.0，11.4）
ACG组	31	17.7（6.2，45.4）^*#
对照组	25	4.7（0.8，7.1）
H值		36.797 8
P值		<0.000 1

房水基质金属蛋白酶-3在青光眼亚型鉴别诊断中的价值

Role of aqueous humor matrix metalloproteinase-3 in the differential diagnosis of glaucoma subtypes

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