原发性高血压患者RDW-CV水平变化及与左心室质量指数的相关性研究

doi:10.3969/j.issn.1673-8640.2015.10.008

检验医学 ›› 2015, Vol. 30 ›› Issue (10): 998-1001.DOI: 10.3969/j.issn.1673-8640.2015.10.008

原发性高血压患者RDW-CV水平变化及与左心室质量指数的相关性研究

刘静¹, 李宾², 刘姝莉², 郑曦¹

1. 咸宁市中心医院检验科,湖北咸宁 437100
2.咸宁市中心医院心内科,湖北咸宁 437100

收稿日期:2015-02-01 出版日期:2015-10-30 发布日期:2015-11-04
作者简介:null
作者简介:刘静,女,1983年生,硕士,主治医师,主要从事血液学与血液细胞诊断学研究。

通讯作者:郑曦,联系电话:0715-8896297。

Research on the relationship between the level changes of RDW-CV and left ventricular mass index in patients with essential hypertension

LIU Jing¹, LI Bin², LIU Shuli², ZHENG Xi¹

1 Department of Clinical Laboratory, Xianning Center Hospital, Hubei Xianning 437100, China
2. Department of Cardiology, Xianning Center Hospital, Hubei Xianning 437100, China

Received:2015-02-01 Online:2015-10-30 Published:2015-11-04

摘要/Abstract

摘要： 目的

探讨原发性高血压(EH)患者红细胞分布宽度变异系数(RDW-CV)水平变化及与左心室质量指数(LVMI)的相关性。

方法

选取100例诊断为EH的患者作为EH组,选取体检正常者30名作为正常对照组。心脏彩色超声多普勒探测相关指标并计算LVMI。根据左心室肥厚(LVH)诊断标准(男性LVMI>125 g/m²,女性LVMI>110 g/m²)将100例EH患者分为EH伴LVH(简称LVH组)40例和EH不伴LVH(简称NLVH组)60例。检测各组血液RDW-CV、红细胞平均体积(MCV)、血红蛋白(Hb)、高敏C反应蛋白(hs-CRP)及左心室射血分数(LVEF)。分析各组RDW-CV水平变化及与LVMI的关系。

结果

3个组之间MCV、Hb及LVEF差异无统计学意义(P>0.05)。NLVH组和LVH组RDW-CV水平及LVMI均明显高于正常对照组(P<0.01);LVH组RDW-CV水平及LVMI均明显高于NLVH组(P<0.01)。Pearson相关性分析结果显示EH患者RDW-CV与LVMI呈正相关(r=0.36,P<0.05)。

结论

EH患者RDW-CV表达水平增高,其变化与LVMI相关。

关键词: 红细胞分布宽度变异系数, 原发性高血压, 左心室质量指数, 左心室肥厚

Abstract: Objective

To investigate the relationship between the level changes of red blood cell distribution width coefficient of variation (RDW-CV) and left ventricular mass index (LVMI) in patients with essential hypertension (EH).

Methods

A total of 100 patients with EH were enrolled as EH group, and 30 healthy subjects were enrolled as healthy control group. Echocardiography was used to measure related indices, and LVMI was calculated. According to the diagnostic criteria of left ventricular hypertrophy (LVH)(LVMI for male>125 g/m² and LVMI for female>110 g/m²), EH group was classified into 2 groups, EH with LVH group (LVH group, 40 cases) and EH without LVH group (NLVH group, 60 cases). RDW-CV, mean corpuscular volume (MCV), hemoglobin (Hb), high-sensitivity C reaction protein (hs-CRP) and left ventricular ejection fraction (LVEF) were determined, and a correlation analysis on RDW-CV level changes and LVMI was performed.

Results

MCV, Hb and LVEF among the 3 groups had no statistical significance (P>0.05). The level of RDW-CV and LVMI in NLVH group and LVH group were significantly higher than those in healthy control group (P<0.01). The level of RDW-CV and LVMI elevated significantly in LVH group than in NLVH group (P<0.01). Pearson linear correlation analysis showed that RDW-CV was positively correlated with LVMI in EH patients(r=0.36, P<0.05).

Conclusions

The expression level of RDW-CV elevates in patients with EH, which is relative to LVMI.

Key words: Red blood cell distribution width coefficient of variation, Essential hypertension, Left ventricular mass index, Left ventricular hypertrophy

中图分类号:

R446.1

刘静, 李宾, 刘姝莉, 郑曦. 原发性高血压患者RDW-CV水平变化及与左心室质量指数的相关性研究[J]. 检验医学, 2015, 30(10): 998-1001.

LIU Jing, LI Bin, LIU Shuli, ZHENG Xi. Research on the relationship between the level changes of RDW-CV and left ventricular mass index in patients with essential hypertension[J]. Laboratory Medicine, 2015, 30(10): 998-1001.

图/表 3

参考文献 12

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组别	例数	RDW-CV(%)	MCV(fL)	Hb(g/L)	hs-CRP(mg/L)	LVEF(%)	LVMI(g/m²)
正常对照组	30	12.66±0.85	86.88±6.82	132.22±11.02	1.66±0.90	56.35±4.76	72.26±7.43
NLVH组	60	14.98±0.93^*	87.75±5.78	130.29±10.53	2.74±0.68^*	55.34±5.01	92.24±8.54^*
LVH组	40	16.95±1.85^*#	85.88±5.84	131.62±12.76	3.91±0.77^*#	55.03±5.23	132.38±9.22^*#

组别	例数	RDW-CV(%)	MCV(fL)	Hb(g/L)	hs-CRP(mg/L)	LVEF(%)	LVMI(g/m²)
正常对照组	30	12.66±0.85	86.88±6.82	132.22±11.02	1.66±0.90	56.35±4.76	72.26±7.43
NLVH组	60	14.98±0.93^*	87.75±5.78	130.29±10.53	2.74±0.68^*	55.34±5.01	92.24±8.54^*
LVH组	40	16.95±1.85^*#	85.88±5.84	131.62±12.76	3.91±0.77^*#	55.03±5.23	132.38±9.22^*#

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原发性高血压患者RDW-CV水平变化及与左心室质量指数的相关性研究

Research on the relationship between the level changes of RDW-CV and left ventricular mass index in patients with essential hypertension

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