doi:10.3969/j.issn.1673-8640.2024.11.017

Abstract

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R378.1

Figures/Tables 5

References 30

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项目	菌株数/株	百分比/%	χ²值	P值
总体	3 138	100.0
性别			32.31	<0.001
男性	1 846	58.8
女性	1 292	41.2
年龄			19.54	0.012
<1 岁	926	29.5
1~<3 岁	765	24.4
3~<6 岁	781	24.9
≥6 岁	666	21.3
年份			4.54	0.471
2015年	532	17.0
2016年	576	18.4
2017年	551	17.6
2018年	505	16.1
2019年	360	11.5
2020年	158	5.0
2021年	279	8.9
2022年	177	5.6
季节			62.22	<0.001
春季	790	25.2
夏季	577	18.4
秋季	688	21.9
冬季	1 083	34.5
病区
门诊	456	14.5
急诊	80	2.5
住院			181.31	<0.001
呼吸科	1 464	46.7
综合内科	385	12.3
重症监护病房	307	9.8
心脏内科	297	9.5
感染科	106	3.4
耳鼻喉科	73	2.3
血液肿瘤科	72	2.3
胸外科	51	1.6
新生儿科	37	1.2
样本类型			77.26	<0.001
痰	1 510	48.1
支气管灌洗液	879	28.0
脓液	192	6.1
外周血	151	4.8
阴道分泌物	150	4.8
耳分泌物	78	2.5
鼻拭子	45	1.4
脑脊液	42	1.3
眼分泌物	21	0.7
胸腔积液	12	0.4

项目	菌株数/株	百分比/%	χ²值	P值
总体	3 138	100.0
性别			32.31	<0.001
男性	1 846	58.8
女性	1 292	41.2
年龄			19.54	0.012
<1 岁	926	29.5
1~<3 岁	765	24.4
3~<6 岁	781	24.9
≥6 岁	666	21.3
年份			4.54	0.471
2015年	532	17.0
2016年	576	18.4
2017年	551	17.6
2018年	505	16.1
2019年	360	11.5
2020年	158	5.0
2021年	279	8.9
2022年	177	5.6
季节			62.22	<0.001
春季	790	25.2
夏季	577	18.4
秋季	688	21.9
冬季	1 083	34.5
病区
门诊	456	14.5
急诊	80	2.5
住院			181.31	<0.001
呼吸科	1 464	46.7
综合内科	385	12.3
重症监护病房	307	9.8
心脏内科	297	9.5
感染科	106	3.4
耳鼻喉科	73	2.3
血液肿瘤科	72	2.3
胸外科	51	1.6
新生儿科	37	1.2
样本类型			77.26	<0.001
痰	1 510	48.1
支气管灌洗液	879	28.0
脓液	192	6.1
外周血	151	4.8
阴道分泌物	150	4.8
耳分泌物	78	2.5
鼻拭子	45	1.4
脑脊液	42	1.3
眼分泌物	21	0.7
胸腔积液	12	0.4

抗菌药物	脑膜炎患儿分离株（42株）				非脑脊液患儿分离株（3 096株）
	PSSP （11株）		PRSP （31株）		PSSP （1 921株）		PISP （1 068株）		PRSP （107株）		合计（3 096株）
	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感
青霉素	0.0	100.0	100.0	0.0	0.0	100.0	0.0	0.0	100.0	0.0	3.5	62.0
头孢呋辛	0.0	100.0	29.0	13.0	7.7	85.2	29.6	42.7	21.8	15.8	15.7	68.2
头孢吡肟	0.0	90.9	77.4	0.0	8.6	66.5	40.0	10.9	43.6	4.0	20.6	45.1
美罗培南	0.0	100.0	45.2	19.4	18.6	53.7	86.7	0.7	89.1	3.0	44.5	33.7
红霉素	100.0	0.0	100.0	0.0	99.2	0.7	100.0	0.0	100.0	0.0	99.6	0.4
克林霉素	100.0	0.0	100.0	0.0	97.8	2.1	100.0	0.0	100.0	0.0	98.7	1.3
四环素	100.0	0.0	100.0	0.0	92.7	6.0	97.5	2.2	98.0	2.0	94.5	4.5
复方磺胺甲噁唑	50.0	50.0	74.2	22.6	58.8	29.8	82.7	8.3	86.1	5.0	68.0	21.8
氯霉素	9.1	90.9	3.2	96.8	8.3	91.7	3.3	96.7	5.0	95.0	6.5	93.5
左氧氟沙星	0.0	100.0	0.0	100.0	0.5	98.9	0.7	90.3	0.0	100.0	5.5	96.0
利奈唑胺	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0
万古霉素	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0

抗菌药物	脑膜炎患儿分离株（42株）				非脑脊液患儿分离株（3 096株）
	PSSP （11株）		PRSP （31株）		PSSP （1 921株）		PISP （1 068株）		PRSP （107株）		合计（3 096株）
	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感
青霉素	0.0	100.0	100.0	0.0	0.0	100.0	0.0	0.0	100.0	0.0	3.5	62.0
头孢呋辛	0.0	100.0	29.0	13.0	7.7	85.2	29.6	42.7	21.8	15.8	15.7	68.2
头孢吡肟	0.0	90.9	77.4	0.0	8.6	66.5	40.0	10.9	43.6	4.0	20.6	45.1
美罗培南	0.0	100.0	45.2	19.4	18.6	53.7	86.7	0.7	89.1	3.0	44.5	33.7
红霉素	100.0	0.0	100.0	0.0	99.2	0.7	100.0	0.0	100.0	0.0	99.6	0.4
克林霉素	100.0	0.0	100.0	0.0	97.8	2.1	100.0	0.0	100.0	0.0	98.7	1.3
四环素	100.0	0.0	100.0	0.0	92.7	6.0	97.5	2.2	98.0	2.0	94.5	4.5
复方磺胺甲噁唑	50.0	50.0	74.2	22.6	58.8	29.8	82.7	8.3	86.1	5.0	68.0	21.8
氯霉素	9.1	90.9	3.2	96.8	8.3	91.7	3.3	96.7	5.0	95.0	6.5	93.5
左氧氟沙星	0.0	100.0	0.0	100.0	0.5	98.9	0.7	90.3	0.0	100.0	5.5	96.0
利奈唑胺	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0
万古霉素	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0

抗菌药物	2015年（524株）		2016年（561株）		2017年（548株）		2018年（504株）		2019年（355株）		2020年（146株）		2021年（281株）		2022年（177株）
抗菌药物	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感	耐药	敏感
青霉素	6.5	52.1	5.2	45.1	3.6	54.2	1.8	56.0	2.5	73.2	1.4	84.2	1.1	91.5	0.6	99.4
头孢呋辛	23.9	55.2	20.1	56.2	15.5	65.3	15.9	67.1	8.7	74.3	3.4	77.4	0.4	88.3	0.6	86.4
头孢吡肟	30.3	34.2	24.6	37.3	17.9	45.8	21.2	42.7	17.5	41.8	17.8	48.0
美罗培南	61.1	21.4	56.3	23.5	46.7	28.7	45.8	34.3	33.0	43.3	25.3	39.1	16.7	54.1	11.3	50.3
红霉素	99.6	0.4	98.4	0.7	99.1	0.9	99.4	0.2	99.2	0.8	98.6	1.4	100.0	0.0	100.0	0.0
克林霉素	99.2	0.8	98.6	1.4	98.2	1.8	98.4	1.6	99.2	0.8	98.6	1.4	95.7	2.5	99.4	0.0
四环素	94.8	4.2	94.0	6.1	94.0	0.9	96.6	3.4	93.5	6.5	93.2	5.4	92.2	7.1	93.2	6.8
复方磺胺甲噁唑	71.6	16.6	70.8	19.1	66.8	20.5	66.1	21.5	67.0	20.8	60.3	32.2	67.2	27.8	78.0	20.3
氯霉素	4.4	95.6	6.4	93.6	6.6	93.5	8.5	91.5	6.5	93.0	4.1	95.9	5.7	94.3	7.3	92.7
左氧氟沙星	0.8	99.2	0.4	99.6	0.2	99.4	1.2	97.8	0.3	98.3	0.7	99.3	0.0	100.0	0.0	100.0
利奈唑胺	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0
万古霉素	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0	0.0	100.0

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