Abstract:

Objective To investigate the roles of serum interferon regulatory factor 4（IRF4） and soluble suppression of tumorigenicity 2（sST2） in patients with oral periimplantitis. Methods Totally，30 patients with oral periimplantitis treated in Cangzhou People's Hospital from January 2021 to December 2022（oral periimplantitis group） were enrolled，and another 30 healthy oral implant subjects（healthy oral implant group） and 30 healthy subjects（healthy control group） were enrolled. Serum levels of IRF4 and sST2 were compared among all the groups. The correlations of serum IRF4 and sST2 levels with age，periodontal depth（PD），gingival sulcus fluid volume and sulcus bleeding index（SBI） were analyzed by Pearson correlation analysis. Receiver operating characteristic（ROC） curve was used to analyze the predictive values of serum IRF4 and sST2 levels in oral periimplantitis. Results PD，gingival sulcus fluid volume and SBI in oral periimplantitis group were higher than those in healthy oral implant group and healthy control group（P<0.05）. Serum IRF4 and sST2 levels in healthy control group，healthy oral implant group and oral periimplantitis group were increased successively（P<0.001）. There was no statistical significance in serum IRF4 and sST2 levels between male and female patients with oral periimplantitis（P>0.05）. Serum IRF4 and sST2 levels in patients ≥60 years old were higher than those in patients <60 years old（P<0.001）. Serum IRF4 and sST2 were positively correlated with age，PD，gingival sulcus fluid volume and SBI（P<0.05）. The areas under curves（AUC） of serum IRF4 and sST2 single and combined determinations were 0.919，0.890 and 0.978，respectively. Conclusions Serum IRF4 and sST2 levels are increased in patients with oral periimplantitis，which are related to periodontal indexes，and they may be used in the diagnosis of oral periimplantitis.

Key words: Interferon regulatory factor 4, Soluble suppression of tumorigenicity 2, Oral periimplantitis