Research progress of COPS5 in tumors

doi:10.3969/j.issn.1673-8640.2019.02.002

Abstract

Abstract:

Constitutively photomorphogenic 9 signalosome subunit 5（COPS5） is an evolutionarily conserved and multifunctional protein that plays a role in signal transduction,cell proliferation,cell apoptosis,cell cycle and the regulation of genomic instability and DNA damage response. COPS5 contributes to oncogenesis by functionally inactivating key negative regulatory proteins and tumor suppressors（P53,P27 and so on）,and it is associated with poor prognosis and chemo-radiotherapy tolerance. The small molecule inhibitors for COPS5 have been developed in the preliminary clinical application. Furthermore,COPS5 may serve as a potential therapeutic target and plays a role in tumor treatment. This review focuses on the function of COPS5 in oncogenesis and the research progress of COPS5 signaling pathways.

Key words: Constitutively photomorphogenic 9 signalosome subunit 5, Tumor, Genomic instability, DNA damage response

CLC Number:

R446.1

CHEN Miaomiao, GUO Lin, LU Renquan. Research progress of COPS5 in tumors[J]. Laboratory Medicine, 2019, 34(2): 98-102.

Figures/Tables 1

References 36

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