›› 2014, Vol. 29 ›› Issue (12): 1263-1267.

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Research advance on mechanisms of hyperhomocysteinemia neurotoxicity

WANG Xiaoyan1, WANG Weiling2   

  1. 1.Shanghai Hongkou District Mental Health Center, Shanghai 200083, China; 2.Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai 200082, China
  • Received:2014-06-17 Online:2014-12-30 Published:2015-01-14

Abstract:

Hyperhomocysteinemia (HHcy) is caused by abnormal metabolism of homocysteine (Hcy). HHcy is not only an independent risk factor for cardiovascular and cerebrovascular diseases,but also closely correlated with a variety of neurodegenerative and mental diseases.HHcy mainly plays a pathogenic role by vascular and neuron neurotoxicity. In this article, we review the mechanisms of HHcy neurotoxicity in recent years.

Key words: Homocysteine, Hyperhomocysteinemia, Neurotoxicity

CLC Number: