Abstract:

Objective To understand the distribution trend of multidrug-resistant strains, in order to provide the reference of decreasing the incidence of multidrug-resistant strain infection. Methods All kinds of samples from Inpatient Department in Jinan Military General Hospital from January 2006 to December 2011 were collected. The strains were identified by VITEK-32 or VITEK-2 COMPACT 60(after November 2007), and the susceptibility testing was determined by Kirby-Bauer method. The data were analyzed statistically by WHO-NET 5.4 software. Results From January 2006 to December 2011, multidrug-resistant strain infection had increasing trend, and the infection rate of extended spectrum beta-lactamases (ESBLs)-producing strains was highest. The infection rates of pandrug-resistant Acinetobacter baumannii (PDR-AB) and extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) increased obviously. Multidrug-resistant strains were mainly in Departments of Health, Neurosurgery, Intensive Care Unit, Surgery and Hematology among the elder and serious patients with long-term use of antibiotics and immunosuppressant. The main clinical manifestation was respiratory tract infection. Conclusions Multidrug-resistant strain hospital infections have increased year by year, and the monitoring of drug resistance should be strengthened. The prevention should be established in order to reduce the rate of hospital infections.

Key words: Multidrug-resistant strain, Clinical distribution, Infection control