Abstract: Objective　To investigate the relationship of highsensitivity cardiac troponin T(hs-cTnT)， cardiac enzyme and electrocardiogram with myocardial injury in handfootmouth disease(HFMD) of children. Methods　The levels of hs-cTnT, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), lactate dehydrogenase isoenzyme 1(LD1), creatine kinase (CK) and creatine kinase MB isoenzyme (CK-MB) were determined in 241 children with HFMD and 203 healthy children. Their electrocardiogram was examined. The levels of hscTnT, the levels of cardiac enzymes, the abnormal rates and electrocardiogram abnormal rates were analyzed between the 2 groups. Results　The levels of hs-cTnT and cardiac enzyme, the abnormal rates and the abnormal rates of ST-T， conduction blockade，bearing premature and pyknocardia in HFMD group were significantly higher than those of control group(P<0.01). The abnormal rate of hs-cTnT was significantly higher than those of cardiac enzymes. Conclusions　The levels of hs-cTnT and cardiac enzymes and electrocardiogram may be indicators for the diagnosis of myocardial injury and heart function in children with HFMD. The level of hs-cTnT has better diagnostic value.

Key words: High sensitivity cardiac troponin T, Cardiac enzyme, Electrocardiogram, Handfootmouth disease