[1]Pennings MT, Derksen RH, van Lummel M, et al. Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2′[J]. J Thromb Haemost, 2007, 5(2): 369-377. [2]Urbanus RT, Siegerink B, Roest M, et al. Anti-phospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study[J]. Lancet Neurol, 2009, 8(11): 998-1005. [3]Van Lummel M, Pennings MT, Derksen RH, et al. The binding site in {beta}2- glycoprotein I for ApoER2′ on platelets is located in domain V[J]. J Biol Chem, 2005, 280(44): 36729-36736.[4] Agar C, van Os GM, Mrgelin M, et al. Beta2-glycoprotein I can exist in 2 conformations:implications for our understanding of the antiphospholipid syndrome[J]. Blood, 2010,116(8):1336-1343.[5]Ioannou Y, Zhang JY, Passam FH, et al. Naturally occurring free thiols within beta 2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury[J]. Blood, 2010, 116(11): 1961-1970.[6]Passam FH , Giannakopoulos B , Miarabshahi P , et al. Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post-translational modification of beta 2 glycoprotein I[J]. J Thromb Haemost, 2011, 9(Suppl1) : 275-282.[7]Rahgozar S, Giannakopoulos B, Yan X , et al. Beta 2-glycoprotein Ⅰ protects thrombin from inhibition by heparin cofactor Ⅱ: potentiation of this effect in the presence of anti-beta2-glycoprotein Ⅰ autoantibodies[J]. Arthritis Rheum, 2008, 58(4): 1146-1155.[8]Kuwana M, Matsuura E, Kobayashi K, et al. Bind-ing of 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells[J]. Blood, 2005,105(4):1552-1557.[9] De Laat BD, Derksen RH, Lummel MV, et al. Patho-genic anti-beta2-glycoprotein I antibodies recognize domain I of beta-glycoprotein I only after a conforma-tional change[J]. Blood, 2006,107(5):1916-1924.[10]Rand JH . A new fish for the β2GPⅠ hook: LPS[J]. Blood , 2011,117(25):6743-6744.[11]White-Adams TC, Berny MA, Tucker EI,et al . Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)[J]. Arterioscler Thromb Vasc Biol, 2009, 29(10): 1602-1607.[12]Romay-Penabad Z, Aguilar-Valenzuela R, Urbanus RT, et al. Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome[J]. Blood, 2011,117(4):1408-1414.[13]Urbanus RT , Pennings MT , Derksen RH, et al. Platelet activation by dimeric beta2-glycoprotein I requires signaling via both glycoprotein Ibalpha and apolipoprotein E receptor 2′[J]. J Thromb Haemost, 2008, 6(8): 1405-1412.[14]White TC, Berny MA, Tucker EI, et al . Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2′[J]. J Thromb Haemost, 2008, 6(6): 995-1002.[15] Stolt PC, Bock HH. Modulation of lipoprotein receptor functions by intracellular adaptor proteins[J]. Cell Signal , 2006,18(10):1560-1571.[16]Pennings MT, van Lummel MV , Derksen RH , et al. Interaction of beta2 -glycoprotein I with members of the low density lipoprotein receptor family[J]. J Thromb Haemost, 2006, 4(8): 1680-1690.[17]Sikara MP, Routsias JG, Samiotaki M, et al. {beta}2 glycoprotein I ({beta}2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of anti-phospholipid syndrome[J]. Blood, 2010,115(3):713-723.[18]Hulstein JJ, de Lenting PJ, de Laat BD, et al.Beta2-glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation[J]. Blood,2007,110(5):1483-1491.[19]Passam FH , Rahgozar S, Qi M ,et al. Redox control of beta2-glycoprotein I-von Willebrand factor inter-action by thioredoxin-1[J]. J Thromb Haemost, 2010,8(8): 1754-1762.[20]Vega-Ostertag ME, Ferrara DE, Romay-Penabad Z, et al. Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation[J]. J Thromb Haemost, 2007, 5(9):1828-1834.[21]Montiel-Manzano G, Romay-Penabad Z, Papalardo de Martinez E, et al. In vivo effects of an inhibitor of nuclear factor-kappa B on thrombogenic properties of antiphospholipid antibodies[J]. Ann N Y Acad Sci, 2007,1108:540-553.