Investigation on the significance of des-gamma-carboxy-prothrombin in the diagnosis of primary hepatocellular carcinoma

doi:10.3969/j.issn.1673-8640.2013.05.009

Abstract

Abstract: Objective　To investigate the diagnosis significance of des-gamma-carboxy-prothrombin (DCP) in patients with primary hepatocellular carcinoma，and to improve the sensitivity and specificity in the diagnosis of primary hepatocellular carcinoma. Methods　A total of 116 patients with primary hepatocellular carcinoma and 57 patients with secondary liver cancer，52 patients with digestive system tumors，50 patients with chronic liver disease，73 patients with other liver diseases and 50 healthy subjects (healthy control group) were enrolled. Their serum DCP and alpha fetoprotein(AFP) levels were determined by chemiluminescence. The receiver operating characteristic (ROC) curve was performed. The best diagnosis cut-off value of primary hepatocellular carcinoma was calculated. Results　The DCP level in primary hepatocellular carcinoma group was significantly higher than those in the other groups (P＜0.05)，and there was no statistical significance among the other 5 groups （P＞0.05）. ROC curve showed that the most suitable diagnosis cut-off value of primary hepatocellular carcinoma was 44.5 mAU/mL. The sensitivity was 74.2% ， and the specificity was 88.6%. The specificity of the combination determination of DCP and AFP was above 96%， and its sensitivity was above 91%. There was no correlation between DCP and AFP (r=0.026，P=0.782). Conclusions　DCP has diagnosis significance in the diagnosis of primary hepatocellular carcinoma，and in primary hepatocellular carcinoma， secondary liver cancer and other benign liver diseases ， it has identification significance. The combination determination of DCP and AFP can improve the diagnosis sensitivity and specificity of primary hepatocellular carcinoma.

Key words: Des-gamma-carboxy-prothrombin , Primary hepatocellular carcinoma , Cut-off value

ZHONG Zhimin，WANG Wei，MO Yundan，DAI Hui. Investigation on the significance of des-gamma-carboxy-prothrombin in the diagnosis of primary hepatocellular carcinoma[J]. , 2013, 28(5): 382-386.

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