The application significance of CD64 index and WBC for the early diagnosis and prognosis of sepsis in children
1. Ningbo College of Health Sciences，Zhejiang Ningbo 315100，China ；2.Department of Clinical Laboratory，Fenghua People′s Hospital，Zhejiang Fenghua 315500，China；3.Yinzhou People′s Hospital，Zhejiang Ningbo 315100，China
WANG Wenjuan 1，WANG Hao 2，CHEN Zhe 3. The application significance of CD64 index and WBC for the early diagnosis and prognosis of sepsis in children[J]. , 2013, 28(5): 416-419.
[1] Bhattacharya S. Blood culture in India:a proposal for a national programme for early detection of sepsis[J]. Indian J Med Microbiol，2005，23(4):220-226.[2]Kerschen EJ， Fernandez JA， Cooley BC， et al. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C[J]. J Exp Med， 2007， 204(10):2439-2448.[3]Riedemann NC， Guo RF， Ward PA. The enigma of sepsis[J]. J Clin Invest， 2003， 112(4): 460- 467.[4] Griffin MP，Moorman JR. Toward the early diagnosis of neonatal sepsis and sepsis-like illness using novel heart rate analysis[J]. Pediatrics， 2001，107(1):97-104.[5]Icardi M， Erickson Y ， Kilborn S ，et al. CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients[J]. J Clin Microbiol， 2009， 47(12):3914-3019.[6] Fossati G， Bucknall RC， Edwards SW. Fcgamma receptors in autoimmune diseases[J]. Eur J Clin Invest， 2001， 31(9):821-831.[7] Barth E， Fischer G， Schneider EM， et al. Differences in the expression of CD64 and mCD14 on poly-morphonuclear cells and on monocytes in patients with septic shock[J]. Cytokine， 2001， 14 (5):299-302.[8]Choo YK， Cho HS， Seo IB，et al.Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis[J]. Korean J Pediatr， 2012， 55(1):11-17.[9]Gros A， Roussel M， Sauvadet E， et al.The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients[J]. Intensive Care Med， 2012， 38(3):445-452.[10]Groselj-Grenc M， Ihan A， Pavcnik-Arnol M， et al. Neutrophil and monocyte CD64 indexes， lipopoly-saccharide-binding protein， procalcitonin and C-reactive protein in sepsis of critically ill neonates and children[J]. Intensive Care Med， 2009，35(11):1950-1958.[11]冯萍，虞培娟，朱雪明.细菌感染患者外周血中性粒细胞表面CD64指数的变化[J].检验医学，2010，25（2）：96-99.[12] 周亮，陈秀.中性粒细胞CD64在新生儿败血症中的应用[J].检验医学，2009，24（10）：751-752.[13]Peduzzi P， Shatney C， Sheagren J，et al. Predictors of bacteremia and gram-negative bacteremia in patients with sepsis. The Veterans Affairs Systemic Sepsis Cooperative Study Group[J]. Arch Intern Med， 1992，152(3):529-535.[14]Hsiao AL， Baker MD. Fever in the new millennium:a review of recent studies of markers of serious bacterial in fection infebrile children[J]. Curr Opin Pediatr， 2005，17(1):56-61.
