Abstract: Objective　To study the expressions of fragile histidine triad (FHIT) gene and tumor suppressor in lung cancer 1 (TSLC1) gene in cervical tissues and the relationship with the occurrence of cervical cancer and human papillomavirus (HPV) infection. Methods　The FHIT and TSLC1 gene expressions and highrisk HPV were detected in normal cervical tissues (20 cases)， lowgrade squamous intraepithelial lesion (LSIL) tissues (20 cases)， highgrade squamous intraepithelial lesion (HSIL) tissues (45 cases) and cervical cancer tissues (33 cases) by realtime polymerase chain reaction (PCR). Results　The rates of HPV infection and FHIT and TSLC1 expressions in normal cervical tissues， LSIL tissues， HSIL tissues and cervical cancer tissues were 0%， 30%， 71% and 100%; 100%， 80%， 36% and 18%; 100%， 75%， 33% and 24%, respectively. Each of the 3 rates was significantly different between the different cervical tissues (P<0.01). Highrisk HPV infection was detected in all the patients with FHIT and TSLC1 gene expression loss. The receiver operating characteristic (ROC) curve analysis showed that detection of FHIT and TSLC1 gene expression loss had diagnostic values for cervical cancer and HSIL. Conclusions　The losses of FHIT and TSLC1 gene expressions may occur at the early stage of cervical cancer after HPV infection. The detections of FHIT and TSLC1 gene expressions in patients with highrisk HPV infection may provide important markers for cervical cancer diagnosis.

Key words: Fragile histidine triad, Tumor suppressor in lung cancer 1, Human papillomavirus;Cervical tissue