[1]Lada O，Benhamou Y，Poynard T，et al. Coexistence of hepatitis B surface antigen（HBsAg）and anti-HBs antibodies in chronic hepatitis B virus carriers：influence of "a" determinant variants[J]. J Virol，2006，80(6)：2968-2975.[2]Colson P，Borentain P，Motte A，et al. Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers[J].Virology，2007，367(1)：30-40. [3]Wang L，Liu H，Ning X，et al. Sequence analysis of the S gene region in HBV DNA from patients positive for both HBsAg and HBsAb tests[J].Hepatol Res，2010，40（12）：1212-1218.[4]李晓斐，王丽娜. 乙型肝炎病毒YMDD变异与基因分型及临床关系的研究[J].检验医学，2011，26（7）：479-481.[5]顾长海. 乙型肝炎病毒基因变异及临床意义[J]. 世界感染杂志，2001，1(4):295-297.[6]Pollicino T，Amaddeo G，Restuccia A，et al. Impact of hepatitis B virus（HBV）preS/S genomic variability on HBV surface antigen and HBV DNA serum levels[J]. Hepatology，2012，56（2）：434-443.[7]Huang X，Qin Y，Zhang P，et al. PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis-B surface antigen and anti-HBs antibodies[J]. J Med Virol，2010，82（1）：23-31.[8]Wang YM，Ng WC，Lo SK. Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen[J]. J Gastroenterol，1999，34（5）：600-606.[9]〖JP 2〗Huang CH，Yuan Q，Chen PJ，et al. Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors[J]. J Hepatol，2012，57(4)：720-729.[10]Ren F，Tsubota A，Hirokawa T，et al. A unique acid substitution，T126I，in human genotype C of hepatitis B virus S gene and its possible influence on antigenic structural change[J]. Gene，2006，383：43-51.[11]Qiu S，Zhang J，Tian Y，et al. Reduced antigenicity of naturally occurring hepatitis B surface antigen variants with substitutions at the amino acid residue 126[J]. Intervirology，2008，51（6）： 400-406.[12]Tian Y，Xu Y，Zhang Z，et al. The amino acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen[J]. J Clin Microbiol，2007，45(9)：2971-2978. [13]Torresi J. The virological and clinical significance of mutations in the overlapping envelope and polymerase genes of hepatitis B virus[J]. J Clin Virol，2002，25（2）： 97-106. [14]Sloan RD，Ijaz S，Moore PL，et al. Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant[J]. Antivir Ther，2008，13(3)：439-447.[15]Lu HY，Zeng Z，Xu XY，et al. Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs[J]. World J Gastroenterol，2006，12(26)：4219-4223.[16]Wang YM，Ng WC，Lo SK，et al. Detection of pre-S/S gene mutations in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen[J]. J Gastroenterol，1999，34(5)：600-606.[17]余文辉，周小梅，周大桥，等. 隐匿性慢性乙型肝炎与乙型肝炎病毒重叠基因突变相关性研究[J].国际检验医学杂志，2007，28（8）：701-704.[18]Ogura Y，Kurosaki M，Asahina Y，et al. Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus[J]. J Infect Dis，1999，180(5)：1444-1451.[19]骆抗先. 乙型肝炎基础和临床[M]. 第3版. 北京：人民卫生出版社，2006：71. [20]Chen Y，Qian F，Yuan Q，et al. Mutations in hepatitis B virus DNA from patients with coexisting HBsAg and anti-HBs[J].J Clin Virol，2011，52（3）：198-203.[21]周吉军，吴玉章，王祥智，等. O-糖基化HBV Pre-S(2）CTL表位分子模建及免疫学活性研究[J].第三军医大学学报，2000，22(10)：961-964.[22]Ramanujam M，Hofmann J，Nakhasi HL，et al. Effect of site-directed asparagine to isoleucine substitutions at the N-linked E1 glycosylation sites on rubella virus viability[J]. Virus Res，2001，81(1-2)：151-156. [23]Gavrilov BK，Rogers K，Fernandez-Sainz IJ，et al. Effects of glycosylation on antigenicity and immunogenicity of classical swine fever virus envelope proteins[J]. Virology，2011，420(2)：135-145. [24]成军，杨守纯．现代肝炎病毒分子病毒学[M]．北京：人民军医出版社，1997：37.[25]Wu C，Zhang X，Tian Y，et al. Biological significance of amino acid substitutions in hepatitis B surface antigen(HBsAg）for glycosylation，secretion，antigenicity and immunogenicity of HBsAg and hepatitis B virus replication[J].J Gen Virol，2010，91（Pt 2）:483-492.[26]刘文军，杨芙蓉，阮力，等. 乙型肝炎表面抗原S-蛋白糖化位点序列的人工变异及其哺乳动物细胞表达产物的性状研究[J]. 病毒学报，1997，13（1）：33-40.[27]Rodriguez-Frias F，Buti M，Jardi R，et al. Genetic alterations in the S gene of hepatitis B virus in patients with acute hepatitis B，chronic hepatitis B and hepatitis B liver cirrhosis before and after liver transplantation[J]. Liver，1999，19(3)：177-182.
