Abstract:

Objective To investigate the changes of glycolipid metabolism markers in elderly patients with benign prostatic hyperplasia（BPH）and their clinical significance．Methods Totally，125 BPH patients （BPH group） and 120 healthy subjects undergoing medical checkups（control group）were enrolled from the Second People's Hospital of Longgang District and Shenzhen Huayinkang Medical Laboratory between May 2023 and December 2023. Glycolipid metabolism marker [fasting blood glucose （FBG），glycated albumin（GA），1，5-anhydroglucitol（1，5-AG），glycated hemoglobin A1c（HbA1c），total cholesterol（TC），triglyceride（TG），low-density lipoprotein cholesterol（LDL-C），high-density lipoprotein cholesterol（HDL-C），small and dense low-density lipoprotein cholesterol（sd-LDL-C），homocysteine（Hcy），lipoprotein-associated phospholipase A2 （Lp-PLA2）] as well as prostate-related indexes [the International Prostate Symptom Score（IPSS），prostate volume（PV），total prostate-specific antigen（t-PSA）and maximum urine flow rate （Qmax）] were determined. Pearson correlation analysis was used to assess the relationship between each index and the IPSS score. Logistic regression analysis was conducted to evaluate the factors influencing the occurrence of BPH. The diagnostic efficacy for BPH was assessed by receiver operating characteristic（ROC）curve. Results Compared to control group，the levels of FBG，GA，1，5-AG，HbA1c，TC，TG，LDL-C，t-PSA，IPSS scores and PV were elevated in BPH group（P<0.05）. Hcy，HDL-C levels and Qmax were decreased，with no statistical significance observed between the 2 groups for sd-LDL-C and Lp-PLA2 levels（P >0.05）. LDL-C，HDL-C，FBG，HbA1c，Qmax and t-PSA were identified as independent risk factors for the development of BPH（P<0.05）. FBG，TC，Hcy，PV and t-PSA levels showed positive correlations with IPSS scores（r values were 0.199 0，0.194 8，0.216 7，0.595 3 and 0.581 7，respectively；P=0.028 7，0.032 2，0.017 0，<0.000 1 and <0.000 1，respectively），while Qmax showed a negative correlation with the IPSS score（r=-0.366 0，P<0.000 1）. The areas under curves（AUC）for diagnosing BPH using FBG，HbA1c，HDL-C，LDL-C，Qmax and t-PSA were 0.812，0.631，0.794，0.658，0.850，0.915 and 0.983 for single and combined determinations，respectively. Conclusions Some glycolipid metabolism markers in elderly BPH patients exhibit changes and may be serve as valuable indicators for the early diagnosis and risk assessment of BPH．

Key words: Glycolipid metabolic marker, Total prostate-specific antigen, International Prostate Symptom Score, Benign prostatic hyperplasia