[1] |
SCHÖNICHEN A,WEBB B A,JACOBSON M P,et al. Considering protonation as a posttranslational modification regulating protein structure and function[J]. Annu Rev Biophys,2013,42:289-314.
|
[2] |
LEACH M D,BROWN A J.Posttranslational modifications of proteins in the pathobiology of medically relevant fungi[J]. Eukaryot Cell,2012,11(2):98-108.
|
[3] |
MERGNER J,SCHWECHHEIMER C.The NEDD8 modification pathway in plants[J]. Front Plant Sci,2014,5:103.
|
[4] |
LUCARIELLO A,TRABUCCO E,SELLITTO C,et al.Localization and modulation of NEDD8 protein in the human placenta[J]. In Vivo,2013,27(4):501-506.
|
[5] |
WANG Y,LUO Z,PAN Y,et al.Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells[J]. Cancer Biol Ther,2015,16(3):420-429.
|
[6] |
JIANG Y,JIA L.Neddylation pathway as a novel anti-cancer target:mechanistic investigation and therapeutic implication[J]. Anticancer Agents Med Chem,2015,15(9):1127-1133.
|
[7] |
KANDALA S,KIM I M,SU H.Neddylation and deneddylation in cardiac biology[J]. Am J Cardiovasc Dis,2014,4(4):140-158.
|
[8] |
SCOTT D C,RHEE D Y,DUDA D M,et al. Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation[J]. Cell,2016,166(5):1198-1214. e24.
|
[9] |
BENNETT E J,RUSH J,GYGI S P,et al.Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics[J]. Cell,2010,143(6):951-965.
|
[10] |
CAMUS S,MÉNENDEZ S,FERNANDES K,et al. The p53 isoforms are differentially modified by Mdm2[J]. Cell Cycle,2012,11(8):1646-1655.
|
[11] |
MARINE J C,LOZANO C.Mdm2-mediated ubiquitylation: p53 and beyond[J]. Cell Death Differ,2010,17(1):93-102.
|
[12] |
BROOKS C L,GU W. p53 ubiquitination:Mdm2 and beyond[J]. Mol Cell,2006,21(3):307-315.
|
[13] |
EMBADE N,FERNÁNDEZ-RAMOS D,VARELA-REY M,et al. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation[J]. Hepatology,2012,55(4):1237-1248.
|
[14] |
GAO F,CHENG J,SHI T,et al.Neddylation of a breast cancer-associated protein recruits a classⅢ histone deacetylase that represses NF kappa B-dependent transcription[J]. Nat Cell Biol,2006,8(10):1171-1177.
|
[15] |
STICKLE N H,CHUNG J,KLCO J M,et al.pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development[J]. Mol Cell Biol,2004,24(8):3251-3261.
|
[16] |
ZUO W,HUANG F,CHIANG Y J,et al.c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type Ⅱ receptor[J]. Mol Cell,2013,49(3):499-510.
|
[17] |
LIU N,ZHANG J,YANG X,et al.HDM2 promotes NEDDylation of hepatitis B virus HBx to enhance its stability and function[J]. J Virol,2017,91(16):e00340-17.
|
[18] |
KIM W,BENNETT E J,HUTTLIN E L,et al.Systematic and quantitative assessment of the ubiquitin-modified proteome[J]. Mol Cell,2011,44(2):325-340.
|
[19] |
ZHAO Y, MORGAN M A, SUN Y.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy[J]. Antioxid Redox Signal, 2014,21(17):2383-2400.
|
[20] |
LI L,WANG M,YU G,et al. Overactivated neddylation pathway as a therapeutic target in lung cancer[J]. J Natl Cancer Inst,2014,106(6):dju083.
|
[21] |
CHEN P,HU T,LIANG Y,et al.Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer[J]. Oncotarget,2015,6(11):9002-9017.
|
[22] |
GAO Q,YU G Y,SHI J Y,et al.Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target[J]. Oncotarget,2014,5(17):7820-7832.
|
[23] |
HUA W,LI C,YANG Z,et al.Suppression of glioblastoma by targeting the overactivated protein neddylation pathway[J]. Neuro Oncol,2015,17(10):1333-1343.
|
[24] |
XIE P,YANG J P,CAO Y,et al.Promoting tumorigenesis in nasopharyngeal carcinoma,NEDD8 serves as a potential theranostic target[J]. Cell Death Dis,2017,8(6):e2834.
|
[25] |
WANG X,ZHANG W,YAN Z,et al.Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells[J]. Oncotarget,2016,7(25):38380-38391.
|
[26] |
WANG J,WANG S,ZHANG W,et al.Targeting neddylation pathway with MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis in renal cell carcinoma[J]. Biochem Biophys Res Commun,2017,490(4):1183-1188.
|
[27] |
BARBIER-TORRES L,DELGADO T C,GARCÍA-RODRÍGUEZ J L,et al. Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer[J]. Oncotarget,2015,6(4):2509-2523.
|
[28] |
WATSON I R,IRWIN M S,OHH M.NEDD8 pathways in cancer,Sine Quibus Non[J]. Cancer Cell,2011,19(2):168-176.
|
[29] |
PAN Z Q,KENTSIS A,DIAS D C,et al.Nedd8 on cullin: building an expressway to protein destruction[J]. Oncogene,2004,23(11):1985-1997.
|
[30] |
PANDEY D,HORI D,KIM J H,et al.NEDDylation promotes endothelial dysfunction: a role for HDAC2[J]. J Mol Cell Cardiol,2015,81:18-22.
|
[31] |
ZHANG Y,LUO Q,WANG N,et al.LRG1 suppresses the migration and invasion of hepatocellular carcinoma cells[J]. Med Oncol,2015,32(5):146.
|
[32] |
MILHOLLEN M,THOMAS M,NARAYANAN U,et al.Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924[J]. Cancer Cell,2012,21(3):388-401.
|
[33] |
SOUCY T A,SMITH P G,MILHOLLEN M A,et al.An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer[J]. Nature,2009,458(7239):732-736.
|
[34] |
SARANTOPOULOS J,SHAPIRO G I,COHEN R B,et al.Phase Ⅰ study of the investigational NEDD8-activating enzyme inhibitor pevonedistat(TAK-924/MLN4924) in patients with advanced solid tumors[J]. Clin Cancer Res,2016,22(4):847-857.
|
[35] |
SHAH J J,JAKUBOWIAK A J,O'CONNOR O A,et al. Phase Ⅰ study of the novel investigational NEDD8-activating enzyme inhibitor pevonedistat(MLN4924) in patients with relapsed/refractory multiple myeloma or lymphoma[J]. Clin Cancer Res,2016,22(1):34-43.
|
[36] |
LI L,LIU B,DONG T,et al.Neddylation pathway regulates the proliferation and survival of macrophages[J]. Biochem Biophys Res Commun,2013,432(3):494-498.
|
[37] |
MILHOLLEN M A,NARAYANAN U,SOUCY T A,et al.Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover[J]. Cancer Res,2011,71(8):3042-3051.
|
[38] |
LAN H,TANG Z,JIN H,et al.Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells[J]. Sci Rep,2016,6:24218.
|
[39] |
ZHANG Y,SHI C C,ZHANG H P,et al.MLN4924 suppresses neddylation and induces cell cycle arrest,senescence,and apoptosis in human osteosarcoma[J]. Oncotarget,2016,7(29):45263-45274.
|
[40] |
HUANG J,ZHOU Y,THOMAS G S,et al.NEDD8 inhibition overcomes CKS1B-induced drug resistance by upregulation of p21 in multiple myeloma[J]. Clin Cancer Res,2015,21(24):5532-5542.
|
[41] |
BUHRMANN C,KRAEHE P,LUEDERS C,et al.Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT[J]. PLoS One,2014,9(9):e107514.
|
[42] |
YAO W T,WU J F,YU G Y,et al.Suppression of tumor angiogenesis by targeting the protein neddylation pathway[J]. Cell Death Dis,2014,5:e1059.
|