GWAS for susceptibility genes of primary open-angle glaucoma

doi:10.3969/j.issn.1673-8640.2016.04.018

Abstract

Abstract:

Primary open-angle glaucoma（POAG） is a kind of complex diseases caused by interaction between multiple genes and environmental factors,and genetic factors play important roles in POAG development. Genome-wide association study（GWAS） is widely applied into genetic research for POAG,and it has obtained a series of research results. This method can analyze candidate susceptibility genes in POAG patients,and quantitatively analyze related genes of endophenotypes. Vertical cup-disc ratio（VCDR）,intraocular pressure（IOP）,central corneal thickness（CCT） and optic disc area（ODA）can also be analyzed. These abnormal phenotype-related genes are crucial in the development of POAG. This article reviews the findings of GWAS for POAG.

Key words: Genome-wide association study, Primary open-angle glaucoma, Susceptibility gene

CLC Number:

R446.5

TANG Binghua, CAO Wenjun. GWAS for susceptibility genes of primary open-angle glaucoma[J]. Laboratory Medicine, 2016, 31(4): 329-333.

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