The progress of anti-carbamylated protein antibody

doi:10.3969/j.issn.1673-8640.2015.08.020

Abstract

Abstract:

The key to the treatment of rheumatoid arthritis(RA) is early diagnosis and treatment. It becomes urgent to find sensitive and specific biomarkers for the early diagnosis of RA. In recent years, anti-carbamylated protein (Carp) antibody is attention. Anti-Carp antibody can improve the susceptibility of anti-citrullinated protein antibody (ACPA)-negative RA patients, and the anti-Carp antibody presents in about 30% ACPA-negative RA patients. Like ACPA, anti-Carp antibody is also a biomarker for the early diagnosis of RA. This paper will give a review of the progress.

Key words: Anti-carbamylated protein antibody, Rheumatoid arthritis, Auto-antibody

CLC Number:

R446.62

CHEN Yiqiong, ZHAO Di, LI Zhi.. The progress of anti-carbamylated protein antibody[J]. Laboratory Medicine, 2015, 30(8): 857-860.

Figures/Tables 1

References 25

[1]	KALLBERG H, PADYUKOV L, PLENGE RM, et al.Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis[J]. Am J Hum Genet, 2007, 80(5): 867-875.
[2]	VAN DER HELM-VAN MIL AH, VERPOORT KNBREEDVELD FC, et al. Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis[J]. Arthritis Res Ther, 2005, 7(5) : R949-R958.
[3]	SHI J, KNEVEL R, SUWANNALAI P, et al.Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage[J]. Proc Natl Acad Sci USA, 2011, 108(42):17372-17377.
[4]	WILLEMZE A, TOES RE, HUIZINGA TW, et al.New biomarkers in rheumatoid arthritis[J]. Neth J Med, 2012, 70(9): 392-399.
[5]	TROUW LA, HUIZINGA TW, TOES RE. Autoimmunity in rheumatoid arthritis: different antigens-common principles[J]. Ann Rheum Dis, 2013,72(Suppl 2): ii132-ii136.
[6]	JAISSON S, PIETREMENT C, GILLERY P.Carbamylation-derived products:bioactive compounds and potential biomarkers in chronic renal failure and atherosclerosis[J]. Clin Chem, 2011, 57(11) : 1499-1505.
[7]	WYNCKEL A, RANDOUX C, MILLART H, et al.Kinetics of carbamylated haemoglobin in acute renal failure[J]. Nephrol Dial Transplant, 2000, 15(8): 1183-1188.
[8]	WANG Z, NICHOLLS SJ, RODRIGUEZ ER, et al.Protein carbamylation links inflammation, smoking, uremia and atherogenesis[J]. Nat Med, 2007, 13(10): 1176-1184.
[9]	BURSKA AN, HUNT L, BOISSINOT M, et al.Autoantibodies to posttranslational modifications in rheumatoid arthritis[J].Mediators inflamm, 2014, 2014:492873.
[10]	SHI J, VAN VEELEN PA, MAHLER M, et al.Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies[J]. Autoimmun Rev,2014, 13(3): 225-230.
[11]	TURUNEN S, KOIVULA MK, RISTELI L, et al.Anticitrulline antibodies can be caused by homocitrulline-containing proteins in rabbits[J]. Arthritis Rheum, 2010, 62(11):3345-3352.
[12]	MYDEL P, WANG Z, BRISSLERT M, et al.Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis[J]. J Immunol, 2010, 184(12): 6882-6890.
[13]	STOOP JN, LIU BS, SHI J, et al.Antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis[J].PLoS One, 2014, 9(7): e102163.
[14]	SCINOCCA M, BELL DA, RACAPÉ M, et al.Antihomocitrullinated fibrinogen antibodies are specific to rheumatoid arthritis and frequently bind citrullinated proteins/peptides[J]. J Rheumatol, 2014, 41(2): 270-279.
[15]	罗静,李小峰. 抗氨基甲酰蛋白抗体在类风湿关节炎诊断的价值[J].中华风湿病学杂志,2014,18(4):280-281.
[16]	张园,崔丽艳,张捷. 类风湿关节炎的早期诊断指标研究进展[J].山东医药,2014,58(19):89-92.
[17]	SHI J, WILLEMZE A, JANSSEN GM, et al.Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method[J]. Ann Rheum Dis, 2013, 72(1): 148-150.
[18]	SHI J, VAN DE STADT LA, LEVARHT EW, et al. Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis[J]. Arthritis Rheum, 2013, 65(4): 911-915.
[19]	SHI J, VAN DE STADT LA, LEVARHT EW, et al. Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis[J]. Ann Rheum Dis, 2014, 73(4): 780-783.
[20]	MANNERS PJ, BOWER C.Worldwide prevalence of juvenile arthritis why does it vary so much[J]. J Rheumatol, 2002, 29(7):1520-1530.
[21]	MULLER PC,ANINK J,SHI J,et al.Anticarbamylated protein (anti-CarP) antibodies are present in sera of juvenile idiopathic arthritis (JIA) patients[J]. Ann Rheum Dis, 2013, 72(12): 2053-2055.
[22]	潘正论,张源潮. 中国内地人群类风湿关节炎与HLA-DRB1 共同表位基因关联性的Meta分析[J].中华风湿病学杂志,2004,8(11):662-668.
[23]	CHATFIELD SM, WICKS IP, STURGESS AD, et al.Anti-citrullinated peptide antibody: death of the rheumatoid factor[J].Med J Aust, 2009, 190(12): 693-695.
[24]	JIANG X, TROUW LA, VAN WESEMAEL TJ, et al.Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies[J]. Ann Rheum Dis, 2014, 73(10): 1761-1768.
[25]	BAX M, HUIZINQA TW, TOES RE.The pathogenic potential of autoreactive antibodies in rheumatoid arthritis[J]. Semin Immunopathol, 2014, 36(3): 313-325.